Hematopoietic stem cell transplantation for cutaneous T-cell lymphoma: Summary of 11 cases from two facilities in Japan and Brazil
Autor: | Jade Cury-Martins, Hiraku Suga, Makoto Sugaya, Phillip Scheinberg, Tomomitsu Miyagaki, Roberta Vasconcelos-Berg, Hideki Fujita, Tomonori Oka, Shinichi Sato, José Antonio Sanches, Koji Izutsu |
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Rok vydání: | 2015 |
Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Dermatology Hematopoietic stem cell transplantation Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Japan hemic and lymphatic diseases medicine Humans Anaplastic large-cell lymphoma Retrospective Studies Mycosis fungoides business.industry Not Otherwise Specified Cutaneous T-cell lymphoma Hematopoietic Stem Cell Transplantation Clinical course General Medicine Middle Aged medicine.disease Lymphoma T-Cell Cutaneous Lymphoma Surgery Transplantation surgical procedures operative 030220 oncology & carcinogenesis Female business Brazil |
Zdroj: | The Journal of Dermatology. 43:638-642 |
ISSN: | 0385-2407 |
Popis: | Some patients with cutaneous T-cell lymphoma (CTCL) show a miserable clinical course and the only option that can induce long-term remission for advanced CTCL may be hematopoietic stem cell transplantation (HSCT). So far, studies on HSCT for CTCL patients have been limited. In this study, we summarized 11 cases with CTCL treated with HSCT, including nine cases in Japan and two cases in Brazil. The patients were five cases with mycosis fungoides (MF), two cases with Sézary syndrome (SS), three cases with anaplastic large cell lymphoma, and one case with primary cutaneous peripheral T-cell lymphoma, not otherwise specified (PTL-NOS). Currently, seven out of 11 cases are alive (at 13-108 months after transplantation) and four died at 15 days to 14 months after transplantation. When focusing on the eight patients who received allogeneic HSCT for MF/SS and PTL-NOS, all four patients at 45 years old or under are alive at present. One case showed relapse in the skin. On the other hand, one out of the other four patients at over 45 years old survived. Engraftment failure was seen in one case and all the other three cases experienced relapse. Although this is only a case series with a small number, our study has suggested that we should be careful about age when treating patients with MF/SS by allogeneic HSCT. |
Databáze: | OpenAIRE |
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