The Effects of High-fat-diet Combined with Chronic Unpredictable Mild Stress on Depression-like Behavior and Leptin/LepRb in Male Rats
| Autor: | Jin Ling Yang, Cyrus S.H. Ho, De Xiang Liu, Roger C.M. Ho, Fang Pan, Hong Jiang |
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| Rok vydání: | 2016 |
| Předmět: |
Leptin
Male Elevated plus maze medicine.medical_specialty Hypothalamus Morris water navigation task Down-Regulation Anxiety Diet High-Fat Hippocampus Open field Article 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Hippocampus (mythology) Animals Obesity RNA Messenger Rats Wistar Depressive Disorder Major Multidisciplinary Leptin receptor Behavior Animal business.industry Depression digestive oral and skin physiology medicine.disease 030227 psychiatry Rats Disease Models Animal Endocrinology Receptors Leptin business 030217 neurology & neurosurgery Stress Psychological |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Leptin plays a key role in the pathogenesis of obesity and depression via the long form of leptin receptor (LepRb). An animal model of comorbid obesity and depression induced by high-fat diet (HFD) combined with chronic unpredictable mild stress (CUMS) was developed to study the relationship between depression/anxiety-like behavior, levels of plasma leptin and LepRb in the brains between four groups of rats, the combined obesity and CUMS (Co) group, the obese (Ob) group, the CUMS group and controls. Our results revealed that the Co group exhibited most severe depression-like behavior in the open field test (OFT), anxiety-like behavior in elevated plus maze test (EMT) and cognitive impairment in the Morris water maze (MWM). The Ob group had the highest weight and plasma leptin levels while the Co group had the lowest levels of protein of LepRb in the hypothalamus and hippocampus. Furthermore, depressive and anxiety-like behaviors as well as cognitive impairment were positively correlated with levels of LepRb protein and mRNA in the hippocampus and hypothalamus. The down-regulation of leptin/LepRb signaling might be associated with depressive-like behavior and cognitive impairment in obese rats facing chronic mild stress. |
| Databáze: | OpenAIRE |
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