DNA-binding antibiotics X-ray structure of the distamycin A analog
| Autor: | S. L. Grokhovsky, G. V. Gurskaya, Zhuze Al, B.P. Gottikh |
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| Rok vydání: | 1979 |
| Předmět: |
Models
Molecular Chemical Phenomena Stereochemistry Chemistry medicine.drug_class Distamycins Molecular Conformation X-ray Carboxamide DNA Crystal structure Biochemistry Genetics and Molecular Biology (miscellaneous) chemistry.chemical_compound X-Ray Diffraction Group (periodic table) Amide X-ray crystallography medicine Molecule Pyrroles |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis. 563:336-342 |
| ISSN: | 0005-2787 |
| DOI: | 10.1016/0005-2787(79)90052-2 |
| Popis: | The crystal structure of the antibiotic distamycin A analog containing two pyrrol carboxamide fragments has been determined. The space group of the crystals is P 2 1 b ; the unit-cell dimensions are a = 11.169, b = 21.535, c = 7.863 A , α = β = 90°, γ = 122.45°, Z = 4. The structure is solved by direct methods, and refined with the full-matrix least-squares procedure. The data on the structure of the pyrrol carboxamide backbone allow the following conclusions to be made about the molecular structure of the distamycin type antibiotics: (i) the amide groups have normal trans-configuration with slightly shortened C-C and C-N bonds adjacent to the pyrrol rings, (ii) the N-methyl groups of the pyrrol rings and the oxygen atoms of the amide groups have the same orientation with respect to the backbone. In the distamycin A analog molecule the pyrrol rings and amide group between them are approximately coplanar. |
| Databáze: | OpenAIRE |
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