Interactions of Phosphate Metabolism With Serious Injury, Including Burns
| Autor: | Craig Porter, Gordon L. Klein, Eric Schryver, Ryan Irick, Linda E. Sousse |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Fibroblast growth factor 23 medicine.medical_specialty BURNS Endocrinology Diabetes and Metabolism chemistry.chemical_element Parathyroid hormone Review SPINAL CORD INJURY 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine TRAUMATIC BRAIN INJURY Internal medicine medicine Orthopedics and Sports Medicine Severe burn Phosphate metabolism Chemistry Phosphorus PARATHYROID HORMONE 030208 emergency & critical care medicine Phosphate PHOSPHORUS 030104 developmental biology Endocrinology Signal transduction Adenosine triphosphate |
| Zdroj: | JBMR Plus |
| ISSN: | 2473-4039 |
| Popis: | Approximately 85% of the body's phosphate pool resides within the skeleton. The remaining 15% is stored as high‐energy phosphates or in its free form, where it acts as a substrate for adenosine triphosphate (ATP) production. Accordingly, phosphate plays a crucial role in energy metabolism. Trauma and critical illness result in a hypermetabolic state in which energy expenditure increases. The impact of trauma and critical illness on the body's phosphate stores and phosphate‐dependent metabolic reactions is poorly understood. We had previously observed that after severe burn trauma, increased energy expenditure is temporally related to a marked reduction in serum concentrations of both parathyroid hormone and fibroblast growth factor 23, both of which have phosphaturic effects. The aim of this article is to describe as far as is known the similarities and differences in phosphate metabolism in different types of injury and to infer what these differences tell us about possible signaling pathways that may link increased phosphate utilization and phosphate retention. © 2017 The Authors. JBMR Plus is published by Wiley Periodicals, Inc. on behalf of the American Society for Bone and Mineral Research. |
| Databáze: | OpenAIRE |
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