Risk of developing major depressive disorder and anxiety disorders among adolescents and adults with atopic dermatitis: A nationwide longitudinal study
| Autor: | Albert C. Yang, Wen Han Chang, Kai Lin Huang, Mu Hong Chen, Chih Ming Cheng, Cheng Ta Li, Ya Mei Bai, Ju Wei Hsu, Tzeng Ji Chen, Tung Ping Su, Shih-Jen Tsai |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Longitudinal study medicine.medical_specialty Adolescent Databases Factual Taiwan Comorbidity Dermatitis Atopic Young Adult Psychiatric history Risk Factors Internal medicine medicine Humans Longitudinal Studies Child Psychiatry Depression (differential diagnoses) Depressive Disorder Depressive Disorder Major Proportional hazards model Incidence Hazard ratio Atopic dermatitis medicine.disease Anxiety Disorders Psychiatry and Mental health Clinical Psychology Anxiety Major depressive disorder Female medicine.symptom Psychology |
| Zdroj: | Journal of Affective Disorders. 178:60-65 |
| ISSN: | 0165-0327 |
| Popis: | Background Previous cross-sectional studies have suggested a comorbid association between atopic dermatitis (AD) and depressive disorder as well as anxiety disorders, but the temporal relationship was not determined. Methods Using the Taiwan National Health Insurance Research Database, 8208 AD patients aged 12 and older without psychiatric history and age-/sex-matched (1:1) controls between 1998 and 2008 were enrolled in our study and followed to the end of 2011. Subjects who developed major depression, any depressive disorder, and anxiety disorders during the follow-up were identified. Results The Cox regression analysis after adjusting for demographic data and atopic comorbidities demonstrated that patients with AD had an elevated risk of developing major depression (hazard ratio [HR]: 6.56, 95% confidence interval [CI]: 3.64–11.84), any depressive disorder (HR: 5.44, 95% CI: 3.99–7.44), and anxiety disorders (HR: 3.57, 95% CI: 2.55–4.98). Stratified by age group, both adolescents and adults with AD were prone to developing major depression (HR: 4.26, 95% CI: 1.39–13.13; HR: 7.56, 95% CI: 3.75–15.23), any depressive disorder (HR: 4.38, 95% CI: 2.09–9.18; HR: 5.66, 95% CI: 4.01–7.99), and anxiety disorders (HR: 5.40, 95% CI: 2.02–14.39; HR: 3.36, 95% CI: 2.38–4.80). Conclusions AD in both adolescence and adulthood increased the risk of developing major depression, any depressive disorder, and anxiety disorders in later life. Further studies would be required to clarify the possible underlying mechanism between AD and depression as well as anxiety disorders. |
| Databáze: | OpenAIRE |
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