Properties of Skin in Chinese Infants: Developmental Changes in Ceramides and in Protein Secondary Structure of the Stratum Corneum
| Autor: | Mitsuyuki Hotta, Takashi Kitahara, Chao Yuan, Yao Xueqiu, Tsutomu Fujimura, Ying Zou, Xuemin Wang, Kyoko Shima, Satoru Naito, Yuki Miyauchi, Ayano Naoe |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Upper Arms Adult Male Ceramide medicine.medical_specialty Article Subject lcsh:Medicine Ceramides Electric Capacitance General Biochemistry Genetics and Molecular Biology 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Asian People Body Water Internal medicine medicine Stratum corneum Humans Buttocks Protein secondary structure Skin barrier function Skin Transepidermal water loss General Immunology and Microbiology integumentary system lcsh:R Infant General Medicine Dermatology Water Loss Insensible Sebum Ester bond 030104 developmental biology Endocrinology medicine.anatomical_structure chemistry Child Preschool Female Epidermis Research Article |
| Zdroj: | BioMed Research International, Vol 2017 (2017) BioMed Research International |
| ISSN: | 2314-6133 |
| DOI: | 10.1155/2017/3594629 |
| Popis: | The properties of infant skin regarding its structure and stratum corneum (SC) properties during development compared to adult skin have been reported only for a few races and body sites. The aim of this study was to understand the developmental changes of skin properties in Chinese infants, focusing on SC ceramides and protein secondary structure, which are important for skin barrier function. Three body sites with distinct characteristics (cheeks, inner upper arms, and buttocks) were assessed. Sixty pairs of Chinese infants and their mothers were measured for SC hydration, transepidermal water loss, ceramide levels, sebum with an ester bond, and protein secondary structure of superficial SC. Skin hydration decreased with age at all body sites. TEWL was similar between the 2–12- and 13–24-month-old groups but was higher than the adult group at the buttocks and inner upper arms and was equal to the adult group at the cheeks. These differences coincided with differences in protein secondary structure. Ceramide and sebum levels were lower in the infant groups. We conclude that both the SC functions and the components of infant skin are still developing and are not fully adapted as in adult skin at each body site examined. |
| Databáze: | OpenAIRE |
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