Goblet-cell mucinous epithelium lining the endometrium and endocervix: evidence of metastasis from an appendiceal primary tumor through the use of cytokeratin-7 and -20 immunostains
| Autor: | Stanley J. Robboy, Babatunde Olatidoye, Stephen R. Gray, Kyu-Rae Kim, William F. Moore, Rex C. Bentley |
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| Rok vydání: | 1998 |
| Předmět: |
Pathology
medicine.medical_specialty Biopsy Uterine Cervical Neoplasms Keratin-20 Epithelium Pathology and Forensic Medicine Ovarian tumor Cytokeratin Intermediate Filament Proteins Medicine Humans Mucinous cystadenoma Fallopian Tubes Ovarian Neoplasms Goblet cell business.industry Keratin 20 Keratin-7 Mucins Obstetrics and Gynecology Middle Aged medicine.disease Primary tumor Endometrial Neoplasms medicine.anatomical_structure Appendiceal Neoplasms Keratin 7 Keratins Female Goblet Cells business Endocervix |
| Zdroj: | International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 17(4) |
| ISSN: | 0277-1691 |
| Popis: | Differential staining with cytokeratin (CK)-7 and CK-20, two members of a complex family of proteins in human epithelial cells, proved critical in showing that the extremely well-differentiated goblet-cell (intestinal) mucinous epithelium lining the surface of the endometrium and endocervix in two patients and the fallopian tube in one was identical to that of the coincident appendiceal neoplasms. One of these patients also had a large ovarian tumor that grossly and microscopically resembled a mucinous cystadenoma of borderline malignancy and would have been considered primary except for the CK stains (CK-20 positive and CK-7 negative), which suggested metastasis from the appendix, presumably by a transtubal route. |
| Databáze: | OpenAIRE |
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