Predictive and Feedback Performance Errors Are Signaled in the Simple Spike Discharge of Individual Purkinje Cells
| Autor: | Timothy J. Ebner, Laurentiu S. Popa, Angela L. Hewitt |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Feedback Psychological Purkinje cell Internal model Sensory system Kinematics Article Purkinje Cells Linear regression Modulation (music) medicine Animals Mathematics Communication business.industry General Neuroscience Pattern recognition Macaca mulatta Biomechanical Phenomena Electrophysiological Phenomena medicine.anatomical_structure Data Interpretation Statistical Linear Models Regression Analysis Female Spike (software development) Artificial intelligence Motor learning business Algorithms Psychomotor Performance |
| Zdroj: | The Journal of Neuroscience. 32:15345-15358 |
| ISSN: | 1529-2401 0270-6474 |
| Popis: | The cerebellum has been implicated in processing motor errors required for on-line control of movement and motor learning. The dominant view is that Purkinje cell complex spike discharge signals motor errors. This study investigated whether errors are encoded in the simple spike discharge of Purkinje cells in monkeys trained to manually track a pseudorandomly moving target. Four task error signals were evaluated based on cursor movement relative to target movement. Linear regression analyses based on firing residuals ensured that the modulation with a specific error parameter was independent of the other error parameters and kinematics. The results demonstrate that simple spike firing in lobules IV–VI is significantly correlated with position, distance, and directional errors. Independent of the error signals, the same Purkinje cells encode kinematics. The strongest error modulation occurs at feedback timing. However, in 72% of cells at least one of theR2temporal profiles resulting from regressing firing with individual errors exhibit two peakR2values. For these bimodal profiles, the first peak is at a negative τ (lead) and a second peak at a positive τ (lag), implying that Purkinje cells encode both prediction and feedback about an error. For the majority of the bimodal profiles, the signs of the regression coefficients or preferred directions reverse at the times of the peaks. The sign reversal results in opposing simple spike modulation for the predictive and feedback components. Dual error representations may provide the signals needed to generate sensory prediction errors used to update a forward internal model. |
| Databáze: | OpenAIRE |
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