Circulating adhesion molecules in patients with virus-related chronic diseases of the liver
| Autor: | Sciacca C, Bruno Cm, D. Cilio, Gaetano Bertino, Gaetana Politi, Anna Elisa Marchese, Lucia Chinnici |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Cirrhosis ICAM-1 Intercellular Adhesion Molecule-1 Liver fibrosis Hepacellular necrosis Vascular Cell Adhesion Molecule-1 AutoAnalyzer VCAM-1 Chronic liver diseases Severity of Illness Index Gastroenterology chemistry.chemical_compound Hepatitis B Chronic Internal medicine Severity of illness medicine Humans Aged Hepatitis Cell adhesion molecule business.industry General Medicine Hepatitis C Chronic Middle Aged medicine.disease chemistry Immunology Brief Reports Female business Biomarkers |
| Zdroj: | Scopus-Elsevier |
| Popis: | AIM: In the inflammatory state, intercellular adhesion molecule-1 (ICAM-1) and vascular cellular adhesion molecule-1 (VCAM-1) play a key role in promoting migration of immunological cells from the circulation to target site. Aim of our study was to investigate soluble forms of these molecules in patients with virus-related chronic liver diseases, to assess their behavior in different pathologies and correlation with severity of liver damage. METHODS: Circulating ICAM-1 and VCAM-1 were assayed by EIA commercial kits (R&D System Co., Abington, UK) in 23 patients with chronic active hepatitis (CH), 50 subjects affected by liver cirrhosis (LC) and 15 healthy controls comparable for sex and age. In patients, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also detected by autoanalyzer. RESULTS: LC patients had significantly higher ICAM-1 values than CH patients (38.567.4 ng/mL vs 20.896.42 ng/mL; P |
| Databáze: | OpenAIRE |
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