Ameliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats
| Autor: | Jiang-Yuan Zhao, Meng-Liang Wen, Yunzhen Zhu, Lanqing Ma, Wen-Jing Liu, Li Bian, Shao-Mei Wu, Hong Liang, Xiangqian Dong, Ming-Gang Li, Xu-Jia Chen, Cheng-Gang Zou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Ginsenosides Apoptosis Diet High-Fat Article Cell Line 03 medical and health sciences Liver disease 0302 clinical medicine Insulin resistance Liver Function Tests Non-alcoholic Fatty Liver Disease Internal medicine medicine Animals Panax notoginseng Cell Proliferation Tissue Inhibitor of Metalloproteinase-1 Multidisciplinary medicine.diagnostic_test biology Chemistry Fatty liver medicine.disease biology.organism_classification Rats Disease Models Animal 030104 developmental biology medicine.anatomical_structure Endocrinology Gene Expression Regulation 030220 oncology & carcinogenesis Hepatocyte Phosphatidylcholines Liver function Liver function tests |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep41144 |
| Popis: | Non-alcoholic fatty liver disease (NAFLD) is a common liver disease, which has no standard treatment available. Panax notoginseng saponines (PNS) have recently been reported to protect liver against hepatocyte injury induced by ethanol or high fat diet (HFD) in rats. Compound K and ginsenoside Rh1 are the main metabolites of PNS. In this study, we evaluated the effects of CK and Rh1 on NAFLD. Rats fed HFD showed significant elevations in liver function markers, lipids, glucose tolerance, and insulin resistance. Treatment with CK or Rh1 either alone or in combination dramatically ameliorated the liver function impairment induced by HFD. Histologically, CK and Rh1 significantly reversed HFD-induced hepatocyte injury and liver fibrosis. In vitro experiments demonstrated that treatment with CK or Rh1 alone or in combination markedly induced cell apoptosis, and inhibited cell proliferation and activation in HSC-T6 cells. Additionally, CK and Rh1, either alone or in combination, also repressed the expression of fibrotic factors TIMP-1, PC-I, and PC-III. Taken together, our results demonstrate that CK and Rh1 have positive effects on NAFLD via the anti-fibrotic and hepatoprotective activity. |
| Databáze: | OpenAIRE |
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