An automated algorithm for the detection of cortical interruptions and its underlying loss of trabecular bone; A reproducibility study

Autor: A. Scharmga, A. van Tubergen, B. van Rietbergen, Kathryn S. Stok, René Weijers, D. Loeffen, Piet Geusens, Cheryl Barnabe, J. de Jong, J. van den Bergh, M. Peters, Steven K. Boyd
Přispěvatelé: Orthopaedic Biomechanics, RS: NUTRIM - R3 - Respiratory & Age-related Health, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, Promovendi NTM, Interne Geneeskunde, Beeldvorming, RS: NUTRIM - R2 - Gut-liver homeostasis, MUMC+: MA Reumatologie (9), MUMC+: DA BV Medisch Specialisten Radiologie (9), MUMC+: MA Orthopedie (9), Orthopedie
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
INFLAMMATORY ARTHRITIS
Arthritis
Metacarpophalangeal Joint
Automation
0302 clinical medicine
High resolution peripheral quantitative computed tomography
Cortical interruptions
Quantitative computed tomography
Reliability (statistics)
Observer Variation
medicine.diagnostic_test
Middle Aged
Precision
Trabecular bone
medicine.anatomical_structure
HR-PQCT
lcsh:R855-855.5
Automated algorithm
Female
Tomography
Algorithms
Research Article
Bone micro-architecture
Adult
lcsh:Medical technology
Bone micro architecture
DISTAL RADIUS
03 medical and health sciences
Image processing
medicine
Humans
QUALITY
Radiology
Nuclear Medicine and imaging
Rheumatoid arthritis
030203 arthritis & rheumatology
EROSIONS
Reproducibility
business.industry
image processing
precision
cortical interruptions
rheumatoid arthritis
high resolution peripheral quantitative computed tomography
bone micro architecture
QUANTITATIVE COMPUTED-TOMOGRAPHY
Reproducibility of Results
RHEUMATOID-ARTHRITIS PATIENTS
Metacarpophalangeal joint
medicine.disease
METACARPOPHALANGEAL JOINTS
030104 developmental biology
FINGER JOINTS
Tomography
X-Ray Computed
Nuclear medicine
business
MICROARCHITECTURE
Zdroj: BMC Medical Imaging, 18(1):13. BioMed Central
BMC Medical Imaging, Vol 18, Iss 1, Pp 1-10 (2018)
BMC Medical Imaging
BMC Medical Imaging, 18:13. BioMed Central Ltd
ISSN: 1471-2342
Popis: Background: We developed a semi-automated algorithm that detects cortical interruptions in finger joints using high-resolution peripheral quantitative computed tomography (HR-pQCT), and extended it with trabecular void volume measurement In this study we tested the reproducibility of the algorithm using scan/re-scan data. Methods: Second and third metacarpophalangeal joints of 21 subjects (mean age 49 (SD 11) years, 17 early rheumatoid arthritis and 4 undifferentiated arthritis, all diagnosed < 1 year ago) were imaged twice by HR-pQCT on the same day with repositioning between scans. The images were analyzed twice by one operator (OP1) and once by an additional operator (OP2), who independently corrected the bone contours when necessary. The number, surface and volume of interruptions per joint were obtained. Intra- and inter-operator reliability and intra-operator reproducibility were determined by intra-class correlation coefficients (ICC). Intra-operator reproducibility errors were determined as the least significant change (LSCSD). Results: Per joint, the mean number of interruptions was 3.1 (SD 3.6), mean interruption surface 4.2 (SD 7.2) mm(2), and mean interruption volume 3.5 (SD 10.6) mm(3) for OP1. Intra- and inter-operator reliability was excellent for the cortical interruption parameters (ICC >= 0.91), except good for the inter-operator reliability of the interruption surface (ICC >= 0.70). The LSCSD per joint was 4.2 for the number of interruptions, 5.8 mm(2) for interruption surface, and 3. 2 mm(3) for interruption volume. Conclusions: The algorithm was highly reproducible in the detection of cortical interruptions and their volume. Based on the LSC findings, the potential value of this algorithm for monitoring structural damage in the joints in early arthritis patients needs to be tested in clinical studies. The study is supported by unrestricted grants from the Weijerhorst foundation (WH-2) and Pfizer (WS2056904). The funders had no role in the design of the study, the collection, analysis and interpretation of the data, and in writing the manuscript.
Databáze: OpenAIRE
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