Bacterial translocation in abdominal trauma and postoperative infections
| Autor: | Ernesto Nieves, Dora I. Ríos, Diego Garzón-Ospina, Luisa F. Tobón, Manuel A. Patarroyo, Miguel A. Ramirez, Andrés Isaza, Arley Gómez, Johnny A. Beltrán |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_treatment Wound infection Surgical wound infection Abdominal Injuries Skin infection Molecular typing Critical Care and Intensive Care Medicine Gastroenterology Intestinal mucosa Postoperative infection Risk Factors Laparotomy Mesenteric lymph nodes Prospective Studies Middle aged Lymph nodes Priority journal Aged 80 and over Gastrointestinal tract Abdominal infection Middle Aged medicine.anatomical_structure Phenotype Female Bacterium isolation Abdominal injury Human Abdominal injuries Adult medicine.medical_specialty Respiratory tract infection Adolescent Clinical article Multilocus sequence typing Trauma Article Sepsis Internal medicine medicine Humans Surgical Wound Infection Mesentery lymph node Aged Chi-Square Distribution business.industry Abdominal Infection medicine.disease Bacterium culture Nonhuman Chi-square distribution High risk patient Postoperative infections Abdominal trauma Risk factors Bacterial translocation Bacterial Translocation Surgery business Prospective studies |
| Zdroj: | Repositorio EdocUR-U. Rosario Universidad del Rosario instacron:Universidad del Rosario |
| ISSN: | 1529-8809 |
| Popis: | Background: Bacterial translocation (BT) describes the passage of bacteria residing into the gastrointestinal tract, through the intestinal mucosa barrier to sterile tissues such as mesenteric lymph nodes (MLN) and other organs. This phenomenon has not been thoroughly studied in patients with trauma to date, and an association between BT and postoperative infection has not been well established so far. Methods: MLNs from 36 patients with abdominal trauma were removed during laparotomy and cultured to detect BT. Postoperative infectious complications in these patients were registered, and both phenotypical and molecular typings (through multilocus sequencing) were carried out for microorganisms isolated from MLN and postoperative infection sites. Associations between clinical variables, BT presence, and postoperative infection development were established. Results: BT was detected in 33% of the patients (n = 12). Postoperative infections were present in 22.2% of the patients (n = 8). A significant statistical difference was found between postoperative infections in patients with BT evidence (41.6%), when compared with patients without BT (12.5%; p = 0.047). Bacteria isolated from infection sites were the same as those cultured in MLN in 40% of the cases (n = 2 of 5), allowing us to establish causality between BT and postoperative infection. Conclusions: There is higher risk of BT in trauma patients, and it is associated with a significant increase of postoperative infections. An abdominal trauma index ?10 was found to be associated with the development of BT. This is the first study describing BT among patients with abdominal trauma, where causality is confirmed at molecular level. Copyright © 2011 by Lippincott Williams and Wilkins. |
| Databáze: | OpenAIRE |
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