Vitamin E and Porphyrin Metabolism in Man
| Autor: | Padmanabhan P. Nair, Hari S. Murty, Jeffrey Quartner, Esteban Mezey, Albert I. Mendeloff |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Adult
Male Vitamin medicine.medical_specialty Chromatography Gas Porphyrins medicine.medical_treatment Urine Chronic liver disease Porphyrias chemistry.chemical_compound Coproporphyrins Internal medicine Porphobilinogen Internal Medicine Humans Vitamin E Medicine Whole blood business.industry Middle Aged medicine.disease Levulinic Acids Alcoholism Endocrinology Porphyria chemistry Water-Soluble Vitamin Female business |
| Zdroj: | Archives of Internal Medicine. 128:411 |
| ISSN: | 0003-9926 |
| DOI: | 10.1001/archinte.1971.00310210087008 |
| Popis: | Four patients with symptoms of porphyria were treated with water soluble vitamin E. In all four patients, urinary excretion of δ-aminolevulinic acid, porphobilinogen, coproporphyrins, and uroporphyrins, which were initially elevated, decreased to normal levels following therapy. The initial vitamin E levels in whole blood which were lower than normal responded to treatment with the vitamin and paralleled clinical improvement. The effects of vitamin E on porphyrin metabolism were examined in a group of six male chronic alcoholic patients without clinical evidence of chronic liver disease. The coproporphyrinuria associated with alcoholism was found to be nonresponsive to vitamin E. Our observations indicate that the action of vitamin E in porphyria is probably not mediated through a reversal of the effects of any concurrent alcoholism. |
| Databáze: | OpenAIRE |
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