Pharmacology of isomeric thiocyanobenzoic acids

Autor:	Carr Cj, John C. Krantz, Bryant Hh
Rok vydání:	1950
Předmět:	chemistry.chemical_compound Smooth muscle biology Isomerism Chemistry Stereochemistry Cyanide biology.protein Cytochrome c oxidase Acids General Biochemistry Genetics and Molecular Biology
Zdroj:	Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 74(2)
ISSN:	0037-9727
Popis:	Summary1. The pharmacologic responses to the three isomeric thiocyanobenzoic acids have been investigated. 2. The meta and para compounds are powerful depressors. This action is not shared by the ortho compound. 3. p-Thiocyanobenzoic acid inactivates cytochrome oxidase in concentrations similar to cyanide. The meta compound is less active and the ortho isomer exhibits little inhibition. 4. All three isomers are relaxants to smooth muscle.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b76d5de6ebfd6a00cd65f5d3c11c312 https://pubmed.ncbi.nlm.nih.gov/15440806 Zobrazit plný text záznamu