Thiation of 2′-Deoxy-5,6-dihydropyrimidine Nucleosides with Lawesson′s Reagent: Characterization of Oxathiaphosphepane Intermediates
| Autor: | Pascale Clivio, Jean-Louis Fourrey, Frédéric Peyrane |
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| Rok vydání: | 2003 |
| Předmět: |
Hot Temperature
Deoxyribose Thiouridine Metals and Alloys Organothiophosphorus Compounds Stereoisomerism General Chemistry General Medicine Pyrimidine Nucleosides Combinatorial chemistry Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound chemistry Reagent Materials Chemistry Ceramics and Composites Nucleic acid Organic chemistry Moiety Lawesson's reagent Uridine Derivative (chemistry) |
| Zdroj: | ChemInform. 34 |
| ISSN: | 1522-2667 0931-7597 |
| DOI: | 10.1002/chin.200327182 |
| Popis: | Treatment of 2'-deoxy-3',5'-dithexyldimethylsilyl-5,6-dihydrouridine with Lawesson's reagent led to the expected C4-thiolated derivative together with a number of oxathiaphosphepane isomers which resulted from the heat reversible incorporation of an AnPS2 unit within the 2'-deoxyribose moiety explaining the subsequent anomerisation of the 5,6-dihydropyrimidine nucleosides. |
| Databáze: | OpenAIRE |
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