The gut virome of healthy children during the first year of life is diverse and dynamic
| Autor: | Horacio Pérez-Juárez, Patricia Morán, Liliana Rojas-Velázquez, Susana López, Angélica Serrano-Vázquez, Blanca Taboada, Celia Ximenez, Javier Torres, Carlos F. Arias, Pavel Isa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Gastrointestinal Diseases Social Sciences Plant Science Pathology and Laboratory Medicine Families Feces Sociology Medicine and Health Sciences Caudovirales Bacteriophages Anelloviridae Human Families Children Multidisciplinary Virome Eukaryota Environmental exposure Medical Microbiology Viral Pathogens Viruses Medicine Pathogens Infants Research Article Science 030106 microbiology Plant Pathogens Zoology Reoviridae Biology Microbiology Plant Viral Pathogens 03 medical and health sciences Parvoviruses Humans Human virome Microbial Pathogens Mexico Virus classification Organisms DNA Viruses Infant Newborn Biology and Life Sciences Infant Plant Pathology Virgaviridae biology.organism_classification Caliciviridae Gastrointestinal Tract Anelloviruses 030104 developmental biology Age Groups People and Places Population Groupings |
| Zdroj: | PLoS ONE, Vol 16, Iss 4, p e0240958 (2021) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | In this work, we determined the diversity and dynamics of the gut virome of infants during the first year of life. Fecal samples were collected monthly, from birth to one year of age, from three healthy children living in a semi-rural village in Mexico. Most of the viral reads were classified into six families of bacteriophages including five dsDNA virus families of the order Caudovirales, with Siphoviridae and Podoviridae being the most abundant. Eukaryotic viruses were detected as early as two weeks after birth and remained present all along the first year of life. Thirty-four different eukaryotic virus families were found, where eight of these families accounted for 98% of all eukaryotic viral reads: Anelloviridae, Astroviridae, Caliciviridae, Genomoviridae, Parvoviridae, Picornaviridae, Reoviridae and the plant-infecting viruses of the Virgaviridae family. Some viruses in these families are known human pathogens, and it is surprising that they were found during the first year of life in infants without gastrointestinal symptoms. The eukaryotic virus species richness found in this work was higher than that observed in previous studies; on average between 7 and 24 virus species were identified per sample. The richness and abundance of the eukaryotic virome significantly increased during the second semester of life, probably because of an increased environmental exposure of infants with age. Our findings suggest an early and permanent contact of infants with a diverse array of bacteriophages and eukaryotic viruses, whose composition changes over time. The bacteriophages and eukaryotic viruses found in these children could represent a metastable virome, whose potential influence on the development of the infant’s immune system or on the health of the infants later in life, remains to be investigated. |
| Databáze: | OpenAIRE |
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