Highly Active Macromolecular Prodrugs Inhibit Expression of the Hepatitis C Virus Genome in the Host Cells
| Autor: | Benjamin M. Wohl, Kaja Zuwala, Jesper Melchjorsen, Anton A. A. Smith, Alexander N. Zelikin, Martin Tolstrup, Pau Ruiz-Sanchis |
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| Rok vydání: | 2014 |
| Předmět: |
Gene Expression Regulation
Viral Polymers viruses Hepacivirus Hepatitis C virus Biomedical Engineering Pharmaceutical Science Genome Viral Hepatitis c virus medicine.disease_cause Antiviral Agents Cell Line Biomaterials chemistry.chemical_compound Polymethacrylic Acids Ribavirin medicine Humans Prodrugs biology Hepatitis C Prodrug medicine.disease biology.organism_classification Virology chemistry Cell culture Drug delivery Intracellular |
| Zdroj: | Ruiz-Sanchis, P, Wohl, B M, Smith, A A A, Zuwala, K, Melchjorsen, J, Tolstrup, M & Zelikin, A N 2015, ' Highly active macromolecular prodrugs inhibit expression of the hepatitis c virus genome in the host cells ', Advanced Healthcare Materials, vol. 4, no. 1, pp. 65-68 . https://doi.org/10.1002/adhm.201400307 |
| ISSN: | 2192-2640 |
| DOI: | 10.1002/adhm.201400307 |
| Popis: | Efficacious, potent, and at the same time nontoxic macromolecular prodrugs of ribavirin are designed taking advantage over prodrug activation by the intracellular milieu. Activity of these prodrugs is illustrated in the cells hosting hepatitis C virus replication and also in the cells implicated in the inflammatory response to the viral infection. |
| Databáze: | OpenAIRE |
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