Eradication of tumor growth by delivering novel photothermal selenium-coated tellurium nanoheterojunctions
| Autor: | Zhen Cai, Yuhua Zhang, Ziheng Guo, Shuzhen Liu, Liping Liu, Yan Qiaoting, Xi Zhu, Zongze Wu, Chuanhong Zhou, Yihai Cao, Jiaqi Zhao, Chenyang Xing, Zhengchun Peng, Hongzhong Wang, Jieyu Wu, Bo Ding, Shiyou Chen, Han Zhang, Chaoying Wei, Dou Wang, Dazhou Huang, Dianyuan Fan |
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| Rok vydání: | 2020 |
| Předmět: |
endocrine system
Chemical Phenomena Materials Science Fluorescent Antibody Technique Metal Nanoparticles Antineoplastic Agents 02 engineering and technology 010402 general chemistry complex mixtures 01 natural sciences Mice Selenium fluids and secretions Cell Line Tumor parasitic diseases medicine Animals Humans Tumor growth Lung cancer Research Articles Cancer Drug Carriers Tumor microenvironment Multidisciplinary business.industry virus diseases SciAdv r-articles Photothermal therapy 021001 nanoscience & nanotechnology medicine.disease Xenograft Model Antitumor Assays 0104 chemical sciences 3. Good health Cancer treatment Disease Models Animal Cancer cell apoptosis Hepatocellular carcinoma Cancer research Tellurium 0210 nano-technology business Biomarkers Research Article |
| Zdroj: | Science Advances |
| ISSN: | 2375-2548 |
| DOI: | 10.1126/sciadv.aay6825 |
| Popis: | We made a big breakthrough in nanomaterial-based cancer therapy by developing nanomaterials consisting of tellurium and selenium. Two-dimensional nanomaterial-based photothermal therapy (PTT) is currently under intensive investigation as a promising approach toward curative cancer treatment. However, high toxicity, moderate efficacy, and low uniformity in shape remain critical unresolved issues that hamper their clinical application. Thus, there is an urgent need for developing versatile nanomaterials to meet clinical expectations. To achieve this goal, we developed a stable, highly uniform in size, and nontoxic nanomaterials made of tellurium-selenium (TeSe)–based lateral heterojunction. Systemic delivery of TeSe nanoparticles in mice showed highly specific accumulation in tumors relative to other healthy tissues. Upon exposure to light, TeSe nanoparticles nearly completely eradicated lung cancer and hepatocellular carcinoma in preclinical models. Consistent with tumor suppression, PTT altered the tumor microenvironment and induced immense cancer cell apoptosis. Together, our findings demonstrate an exciting and promising PTT-based approach for cancer eradication. |
| Databáze: | OpenAIRE |
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