| Autor: |
Arul M. Chinnaiyan, A. Robert MacLeod, Youngsoo Kim, Ajjai S. Alva, Xuhong Cao, Alice Xu, Kristin M. Juckette, Andrew Delekta, Esther Luo, Xiaojun Jing, Fengyun Su, Heng Zheng, Xiaoju Wang, Sudhanshu Shukla, Yuanyuan Qiao, Lisha Wang, Yajia Zhang, Abhijit Parolia, Mengyao Tan, Josh Vo, Jean C. Tien, Lanbo Xiao |
| Rok vydání: |
2023 |
| Popis: |
This file includes Supplementary Figures S1-S8. Figure S1: Inhibition of EPZ6438 and ASO-EZH2 sensitizes enzalutamide-resistant LNCaP cells to enzalutamide or ASO-AR. Figure S2: Design and validation of sgRNA targeting EZH2. Figure S3: Growth inhibitory effect of Enzalutamide in EZH2 loss-of-function CRPC cell lines. Figure S4: Knockdown efficiency of ASO-AR and ASO-EZH2 in CRPC cell lines. Figures S5: EZH2 ASOs inhibit proliferation of LNCaP-abl cells. Figure S6: EZH2 ASOs synergize with ASO-AR to inhibit growth of prostate cancer cells in soft-agar colony formation assay and Cell-titer Glo assay. Figure S7: Loss-of-function of EZH2 alters AR cistrome. Figure S8: Tumor characterization of xenografted study. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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