Trial of antihypertensive intervention and management: greater efficacy with weight reduction than with a sodium-potassium intervention
| Autor: | Barry R. Davis, M. Donald Blaufox, Heidi Hataway, Albert Oberman, Neal Zimbaldi, Stephanie Jennings, Herbert G. Langford, Judith Stern, Sylvia Wassertheil-Smoller, Judith Wylie-Rosett |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Diet Reducing Diet therapy medicine.medical_treatment Potassium Sodium chemistry.chemical_element Blood Pressure Weight loss Internal medicine Medicine Humans Obesity Analysis of Variance Nutrition and Dietetics business.industry Weight change Body Weight Chlorthalidone Potassium Dietary Sodium Dietary Middle Aged Combined Modality Therapy Diet Records Endocrinology chemistry Atenolol Hypertension Female Diuretic medicine.symptom business Food Science medicine.drug Low sodium |
| Zdroj: | Journal of the American Dietetic Association. 93(4) |
| ISSN: | 0002-8223 |
| Popis: | The Trial of Antihypertensive Intervention and Management evaluated nine diet-drug combinations in 878 mildly hypertensive, moderately obese participants using a 3 × 3 factorial design. Drugs evaluated were placebo, diuretic (chlorthalidone), and β-blocker (atenolol); diets were usual (no intervention), weight reduction, and low sodium/high potassium (NaK). This article reports 6-month dietary changes and the effect of dietary change on blood pressure. Six-month mean weight change was −4.7 kg in the weight reduction group, −0.3 kg in the NaK group, and −0.5 kg in the usual-diet group. At 6 months, daily electrolyte excretion had changed in the NaK intervention group. Daily sodium excretion decreased from 138.0 to 112.0 mmol in the NaK group and increased from 134.1 to 138.4 mmol in the weight reduction group and from 129.1 to 137.0 mmol in the usual-diet group. Daily potassium output increased from 58.7 to 71.4 mmol in the NaK group, from 57.0 to 60.5 mmol in the weight reduction group, and from 55.3 to 59.1 mmol in the usual diet group. Analysis of 3-day food records indicated that sodium intake decreased from 141.1 to 85.8 mmol and potassium intake increased from 76.4 to 90.5 mmol. Our results indicate that the goal for weight reduction was more easily achieved than the goal for electrolyte modification. |
| Databáze: | OpenAIRE |
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