Changes in long-term sebum production from isotretinoin therapy
| Autor: | John S. Strauss, Anna M. Stranieri |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Sebaceous gland
medicine.medical_specialty Nodulocystic acne Sebum production Retinoic acid Physiology Tretinoin Dermatology Isotretinoin therapy chemistry.chemical_compound Double-Blind Method Isomerism Acne Vulgaris Medicine Humans In patient Isotretinoin Sebaceous gland activity Clinical Trials as Topic business.industry Sebum medicine.anatomical_structure chemistry business medicine.drug |
| Zdroj: | Journal of the American Academy of Dermatology. 6(4 Pt 2) |
| ISSN: | 0190-9622 |
| Popis: | Sebum production has been measured in twenty patients in whom 13- cis -retinoic acid therapy had been discontinued for at least 20 weeks. While sebum production had returned to pretreatment levels by 30 weeks in seven subjects, 30% to 80% reduction in sebaceous gland activity was still present for as long as 80 weeks in eight subjects. Four of these eight patients, who were followed for more than a year, still had marked sebaceous inhibition when last tested. The prolonged remission seen in patients with nodulocystic acne may be related in part to continued sebaceous gland inhibition in some patients, but it obviously is not the only factor responsible for the long-term improvement that is seen. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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