Mechanisms of Fluoride Toxicity: From Enzymes to Underlying Integrative Networks
| Autor: | Anna Strunecká, Otakar Strunecky |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
autism spectrum disorders
enzymes Physiology 010501 environmental sciences 01 natural sciences lcsh:Technology lcsh:Chemistry 03 medical and health sciences chemistry.chemical_compound Human health Endemic fluorosis Fluoride toxicity medicine General Materials Science Water fluoridation Instrumentation lcsh:QH301-705.5 030304 developmental biology 0105 earth and related environmental sciences Fluid Flow and Transfer Processes 0303 health sciences business.industry lcsh:T Process Chemistry and Technology General Engineering Neurotoxicity medicine.disease lcsh:QC1-999 Computer Science Applications fluoride toxicity chemistry lcsh:Biology (General) lcsh:QD1-999 lcsh:TA1-2040 aluminofluoride complexes business lcsh:Engineering (General). Civil engineering (General) Fluoride lcsh:Physics G proteins IQ deficits |
| Zdroj: | Applied Sciences, Vol 10, Iss 7100, p 7100 (2020) |
| ISSN: | 2076-3417 |
| Popis: | Fluoride has been employed in laboratory investigations since the early 20th century. These studies opened the understanding of fluoride interventions to fundamental biological processes. Millions of people living in endemic fluorosis areas suffer from various pathological disturbances. The practice of community water fluoridation used prophylactically against dental caries increased concern of adverse fluoride effects. We assessed the publications on fluoride toxicity until June 2020. We present evidence that fluoride is an enzymatic poison, inducing oxidative stress, hormonal disruptions, and neurotoxicity. Fluoride in synergy with aluminum acts as a false signal in G protein cascades of hormonal and neuronal regulations in much lower concentrations than fluoride acting alone. Our review shows the impact of fluoride on human health. We suggest focusing the research on fluoride toxicity to the underlying integrative networks. Ignorance of the pluripotent toxic effects of fluoride might contribute to unexpected epidemics in the future. |
| Databáze: | OpenAIRE |
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