The Outcomes of Enamel Matrix Derivative on Periodontal Regeneration under Diabetic Conditions
| Autor: | Florin Onisor, Alexandru Mester, Laura Elena Narita, Simion Bran, Maria Ioana Onicas, Andrada Voina-Tonea |
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| Rok vydání: | 2021 |
| Předmět: |
Medicine (General)
Alveolar Bone Loss Dentistry Bone healing Regenerative medicine Diabetes Mellitus Experimental R5-920 Dental Enamel Proteins Osteogenesis enamel matrix proteins Diabetes mellitus periodontal regeneration Enamel matrix derivative EMD Animals Medicine tissue repair Cementum Wound Healing diabetes business.industry Regeneration (biology) General Medicine medicine.disease Rats Clinical trial medicine.anatomical_structure Systematic Review Animal studies business |
| Zdroj: | Medicina Medicina, Vol 57, Iss 1071, p 1071 (2021) |
| ISSN: | 1648-9144 |
| DOI: | 10.3390/medicina57101071 |
| Popis: | Background and Objectives: Enamel matrix derivative (EMD) is a biomaterial used for periodontal regenerative therapy due to its properties of stimulating cementum development and bone synthesis. Diabetes is a chronic condition that affects healing and predisposes to infection. The aim of this review was to evaluate the current studies available on the application and results of EMD for periodontal regenerative therapy under diabetic conditions. Materials and Methods: Five databases (PubMed, ResearchGate, Scopus, Web of Science and Google Scholar) were searched for relevant articles, using specific keywords in different combinations. The inclusion criteria were clinical trials, case reports, case studies, and animal studies published in English, where periodontal treatment for bone defects includes EMD, and it is performed under diabetic conditions. Results: Of the 310 articles resulted in search, five studies published between 2012 and 2020 met the inclusion criteria and were selected for the current review. In human studies, the use of EMD in infrabony defects showed favorable results at follow-up. In animal studies, periodontal regeneration was reduced in diabetic rats. Conclusions: EMD might promote bone healing when used under diabetic conditions for the regenerative periodontal therapy. Due to limited number of studies, more data are required to sustain the effects of EMD therapy in diabetic settings. |
| Databáze: | OpenAIRE |
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