Variations in Disrupted-in-Schizophrenia 1 gene modulate long-term longitudinal differences in cortical thickness in patients with a first-episode of psychosis

Autor: Adele Ferro, Lourdes Fañanás, Javier Vázquez-Bourgon, Benedicto Crespo-Facorro, Roberto Roiz-Santiañez, Sergi Papiol, Noemí Varela-Gomez
Rok vydání: 2015
Předmět:
Oncology
Adult
Male
medicine.medical_specialty
Psychosis
Cognitive Neuroscience
Single-nucleotide polymorphism
Nerve Tissue Proteins
Polymorphism
Single Nucleotide
White People
03 medical and health sciences
Behavioral Neuroscience
Cellular and Molecular Neuroscience
DISC1
0302 clinical medicine
Internal medicine
medicine
Humans
Radiology
Nuclear Medicine and imaging
Longitudinal Studies
Prospective Studies
Allele
First episode
Cerebral Cortex
biology
Neuropsychology
Organ Size
medicine.disease
Magnetic Resonance Imaging
030227 psychiatry
Psychiatry and Mental health
Cross-Sectional Studies
Treatment Outcome
Neurology
Psychotic Disorders
Schizophrenia
Spain
Endophenotype
Acute Disease
biology.protein
Disease Progression
Female
Neurology (clinical)
Psychology
Neuroscience
030217 neurology & neurosurgery
Follow-Up Studies
Zdroj: Brain imaging and behavior. 10(3)
ISSN: 1931-7565
Popis: Schizophrenia patients typically present a widespread bilateral cortical thinning from the early stages of the illness. However, there is controversy whether this reduction in cortical thickness (CT) is static or progressive over the evolution of the disorder. Disrupted-in-Schizophrenia 1 (DISC1) is one of the main candidates genes for schizophrenia, as it has been found associated to the illness, and to several endophenotypes of the disorder including structural brain differences. This gene is known to be involved in neurodevelopment and brain maturation processes. We therefore hypothesized that variations in this gene modulate different progressions of CT in psychosis. Seventy-nine Caucasian drug-naive patients experiencing a first episode of non-affective psychosis were genotyped for rs6675281 (Leu607Phe) and rs821616 (Ser704Cys) SNPs of the DISC1 gene. Brain MRIs were carried out at baseline and 3 years after initiating the treatment. Other clinical and socio-demographic variables were recorded to rule out possible confounding effects. Patients homozygous for the Leu allele of the rs6675281 SNP had a significant (p < 0.05) descend in CT over the 3-years period, while those carrying the Phe allele presented an increase in CT. When combining the two SNPs we found a synergic effect on CT progression, presenting those patients homozygous for Leu607 +Ser704 a more pronounced cortical thinning. In conclusion, DISC1 gene variations may modulate the longitudinal changes in cortical thickness in patients suffering from a first episode of non-affective psychosis.
Databáze: OpenAIRE
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