Acid-secretory response and parietal cell sensitivity in patients with duodenal ulcer before and after treatment with sucralfate or ranitidine
| Autor: | Nel A. Tigler-Wybrandi, G. O. Young, Marks In, Keith Newton, Sharon Bridger |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Sucralfate Ranitidine Gastroenterology Bedtime Gastric Acid Parietal Cells Gastric Internal medicine medicine Humans Parietal cell business.industry General Medicine Middle Aged Duodenal ulcer Pentagastrin medicine.anatomical_structure Basal (medicine) Duodenal Ulcer Female business After treatment Histamine medicine.drug |
| Zdroj: | The American Journal of Medicine. 86:145-147 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/0002-9343(89)90177-0 |
| Popis: | Patients with endoscopically proved duodenal ulcer were randomly assigned to treatment with either ranitidine 300 mg at bedtime or sucralfate 2 g twice daily for six weeks. Acid-secretory studies were performed before commencement and 60 to 84 hours after cessation of treatment and endoscopic healing was confirmed. Patients were randomly assigned to receive a constant infusion of secretory stimulant: either pentagastrin 0.1 and 6.0 micrograms/kg/hour or histamine acid phosphate 4.0 and 40 micrograms/kg/hour. Acid output in mmol/hour was measured for basal, low dose, and high dose output. Parietal cell sensitivity (PCS) was calculated as the ratio of low-dose acid output: high-dose acid output and expressed as a percentage. Values before and after treatment were compared and significance of differences was determined using the Student paired t test. There was an apparent decrease in basal acid output, low-dose acid output, high-dose acid output, and PCS with ulcer healing, regardless of treatment or stimulant used. Basal acid output, low-dose acid output, high-dose acid output, and PCS were significantly lower in the sucralfate-treated group, but only high-dose acid output decreased significantly in the ranitidine-treated group. These differences may be relevant to early duodenal ulcer relapse in ranitidine-treated patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|