The Breast Cancer Stem Cells Traits and Drug Resistance
| Autor: | Mengdi Zhang, Long Zhang, Fangfang Zhou, Xuli Meng, Qinghui Zheng |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
breast cancer stem cells
Oncology medicine.medical_specialty medicine.medical_treatment Review Drug resistance Targeted therapy Metastasis Efficacy Breast cancer Internal medicine medicine breast cancer stem cell signaling pathways Pharmacology (medical) Pharmacology Chemotherapy drug resistance business.industry surface markers lcsh:RM1-950 Endocrine therapy clinical therapy medicine.disease lcsh:Therapeutics. Pharmacology Stem cell business |
| Zdroj: | Frontiers in Pharmacology, Vol 11 (2021) Frontiers in Pharmacology |
| ISSN: | 1663-9812 |
| DOI: | 10.3389/fphar.2020.599965 |
| Popis: | Drug resistance is a major challenge in breast cancer (BC) treatment at present. Accumulating studies indicate that breast cancer stem cells (BCSCs) are responsible for the BC drugs resistance, causing relapse and metastasis in BC patients. Thus, BCSCs elimination could reverse drug resistance and improve drug efficacy to benefit BC patients. Consequently, mastering the knowledge on the proliferation, resistance mechanisms, and separation of BCSCs in BC therapy is extremely helpful for BCSCs-targeted therapeutic strategies. Herein, we summarize the principal BCSCs surface markers and signaling pathways, and list the BCSCs-related drug resistance mechanisms in chemotherapy (CT), endocrine therapy (ET), and targeted therapy (TT), and display therapeutic strategies for targeting BCSCs to reverse drug resistance in BC. Even more importantly, more attention should be paid to studies on BCSC-targeted strategies to overcome the drug resistant dilemma of clinical therapies in the future. |
| Databáze: | OpenAIRE |
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