Seroprevalence of hepatitis B virus: Findings from a population-based household survey in KwaZulu-Natal, South Africa
| Autor: | Cheryl Baxter, Cherie Cawood, Ayesha B. M. Kharsany, Lara Lewis, Sinaye Ngcapu, Natasha Samsunder, David Khanyile |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male HBsAg medicine.disease_cause HBeAg South Africa 0302 clinical medicine Seroepidemiologic Studies Surveys and Questionnaires HIV Seropositivity Prevalence 030212 general & internal medicine Hepatitis B e Antigens Hepatitis B virus (HBV) prevalence education.field_of_study biology Coinfection virus diseases General Medicine Middle Aged Hepatitis B 3. Good health Infectious Diseases Female Antibody Microbiology (medical) Adult medicine.medical_specialty Hepatitis B virus Adolescent 030106 microbiology Population Article lcsh:Infectious and parasitic diseases 03 medical and health sciences Young Adult medicine Seroprevalence Humans lcsh:RC109-216 Hepatitis B Antibodies education Hepatitis B Surface Antigens business.industry Public health HBV-HIV co-infection Confidence interval digestive system diseases Anti-HBe biology.protein business Demography |
| Zdroj: | International Journal of Infectious Diseases, Vol 85, Iss, Pp 150-157 (2019) International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases |
| ISSN: | 1201-9712 |
| Popis: | Background: Hepatitis B virus (HBV) infection is a major cause of morbidity and mortality; however, little is known about the prevalence and distribution of HBV in some populations and regions. Methods: A total of 9791 participants, 15–49 years old, were enrolled in a household survey in KwaZulu-Natal, South Africa. Peripheral blood samples were tested for markers of HBV (hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), antibody to HBeAg (anti-HBe)) and analysed, accounting for multilevel sampling and weighted to represent the population. Results: Overall HBsAg prevalence was 4.0% (95% confidence interval (CI) 3.4–4.5%): 4.8% (95% CI 3.8–5.8%) in men and 3.2% (95% CI 2.5–3.9%) in women (p = 0.01). Among HBsAg-positive participants, 35.2% (95% CI 29.2–41.2%) were HBeAg-positive and 66.3% (95% CI 60.1–72.4%) were anti-HBe-positive. HBsAg prevalence was 6.4% (95% CI 5.3–7.5%) among HIV-positive participants compared to 2.6% (95% CI 1.9–3.2%) among HIV-negative participants (p |
| Databáze: | OpenAIRE |
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