Lung histopathological findings in COVID-19 disease – a systematic review
| Autor: | Maria Antonietta Ramunno, Mario Meccariello, Alessio Agostinone, Giuseppe Pannone, Franco M. Buonaguro, Maria Eleonora Bizzoca, Shailesh Advani, Lorenzo Lo Muzio, Ilenia Sara De Stefano, Silvana Papagerakis, Khrystyna Zhurakivska, Vito Carlo Alberto Caponio, Giuseppe Troiano, Maria Carmela Pedicillo, Tommaso Cassano |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_specialty Pathology ARDS Epidemiology Histopathology Review Infectious and parasitic diseases RC109-216 030204 cardiovascular system & hematology Alveolar cells 03 medical and health sciences 0302 clinical medicine Immune system medicine Type-I Pneumocytes Diffuse alveolar damage Lung RC254-282 030304 developmental biology 0303 health sciences business.industry Type-II Pneumocytes COVID-19 Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Infectious Diseases medicine.anatomical_structure Oncology Systematic review Therapy business |
| Zdroj: | Infectious Agents and Cancer, Vol 16, Iss 1, Pp 1-18 (2021) Infectious Agents and Cancer |
| ISSN: | 1750-9378 |
| Popis: | Since December 2019, the global burden of the COVID-19 pandemic has increased rapidly and has impacted nearly every country in the world, affecting those who are elderly or with underlying comorbidities or immunocompromised states. Aim of this systematic review is to summarize lung histopathological characteristics of COVID-19, not only for diagnostic purpose but also to evaluate changes that can reflect pathophysiological pathways that can inform clinicians of useful treatment strategies. We identified following histopathological changes among our patients:: hyaline membranes; endothelial cells/ interstitial cells involvement; alveolar cells, type I pneumocytes/ type II pneumocytes involvement; interstitial and/ or alveolar edema; evidence of hemorrhage, of inflammatory cells, evidence of microthrombi; evidence of fibrin deposition and of viral infection in the tissue samples. The scenario with proliferative cell desquamation is typical of Acute Respiratory Distress Syndrome (ARDS) that can be classified as diffuse alveolar damage (DAD) and not DAD-ARDS. The proposed pathological mechanism concerns the role of both innate and adaptive components of the immune system. COVID-19 lethal cases present themselves as a heterogeneous disease, characterized by the different simultaneous presence of different histological findings, which reflect histological phases with corresponding different pathological pathways (epithelial, vascular and fibrotic changes), in the same patient. Supplementary Information The online version contains supplementary material available at 10.1186/s13027-021-00369-0. |
| Databáze: | OpenAIRE |
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