The effects of Commiphora mukul extract on spermatogenesis and testosterone levels in male diabetic rats
| Autor: | Mehdi Rahnama, Iraj Salehi, Seyed Asaad Karimi, Ali Akbar Rezaei |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Streptozotocin business.industry medicine.medical_treatment education Intraperitoneal injection Motility Commiphora mukul medicine.disease Sperm Rats Diabetes mellitus Endocrinology Reproductive Medicine Internal medicine medicine Original Article Increased serum testosterone level business Spermatogenesis Testosterone medicine.drug |
| Zdroj: | Clinical and Experimental Reproductive Medicine |
| ISSN: | 2233-8241 2233-8233 |
| Popis: | Objective: The strong antioxidant activity of Commiphora mukul prompted us to conduct the present study to explore whether treatment with C. mukul extract (CME) would have any protective influence on sperm parameters, testosterone levels, and plasma glucose levels in streptozotocin (STZ)-induced diabetic rats.Methods: Male Wistar rats were randomly divided into four groups: control, control animals treated with CME, diabetic animals, and diabetic animals treated with CME. CME extract (300 mg/kg) was administered for 60 days by daily gavage. Diabetes was induced by an intraperitoneal injection of 50 mg/kg STZ. The epididymal sperm count, weight, motility, morphology, viability, and serum testosterone and glucose levels were determined.Results: In the diabetic animals, CME decreased blood glucose levels (ppppp=0.003). Furthermore, in diabetic animals, CME decreased the proportion of immotile sperm (ppp=0.035), but treatment of diabetic animals with CME increased serum testosterone levels.Conclusion: The present study demonstrated that C. mukul possesses proandrogenic activity and exerts a beneficial effect on sperm parameters in diabetic rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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