Synthesis and applications of high-performance P-chiral phosphine ligands
| Autor: | Tsuneo Imamoto |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
inorganic chemicals
catalytic asymmetric synthesis enantioselection mechanism Phosphines Chemistry organic chemicals Asymmetric hydrogenation Enantioselective synthesis P-chiral phosphine ligand General Physics and Astronomy Review General Medicine Optically active Ligands asymmetric hydrogenation Combinatorial chemistry Catalysis Important research chemistry.chemical_compound phosphine–borane Rhodium Hydrogenation General Agricultural and Biological Sciences Phosphine Electronic properties |
| Zdroj: | Proceedings of the Japan Academy. Series B, Physical and Biological Sciences |
| ISSN: | 1349-2896 0386-2208 |
| DOI: | 10.2183/pjab.97.026 |
| Popis: | Metal-catalyzed asymmetric synthesis is one of the most important methods for the economical and environmentally benign production of useful optically active compounds. The success of the asymmetric transformations is significantly dependent on the structure and electronic properties of the chiral ligands coordinating to the center metals, and hence the development of highly efficient ligands, especially chiral phosphine ligands, has long been an important research subject in this field. This review article describes the synthesis and applications of P-chiral phosphine ligands possessing chiral centers at the phosphorus atoms. Rationally designed P-chiral phosphine ligands are synthesized by the use of phosphine-boranes as the intermediates. Conformationally rigid and electron-rich P-chiral phosphine ligands exhibit excellent enantioselectivity and high catalytic activity in various transition-metal-catalyzed asymmetric reactions. Recent mechanistic studies of rhodium-catalyzed asymmetric hydrogenation are also described. |
| Databáze: | OpenAIRE |
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