Recurrent Implantation Failure-update overview on etiology, diagnosis, treatment and future directions

Autor: Katherine Ida Halper, Raoul Orvieto, Asher Bashiri
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
medicine.medical_specialty
lcsh:QH471-489
medicine.medical_treatment
Uterus
Reproductive medicine
Review
Fertilization in Vitro
Bioinformatics
lcsh:Gynecology and obstetrics
03 medical and health sciences
0302 clinical medicine
Endocrinology
Recurrence
Risk Factors
Recurrent implantation failure-RIF
medicine
Humans
lcsh:Reproduction
Advanced maternal age
Embryo Implantation
Treatment Failure
Progesterone
Preimplantation Diagnosis
lcsh:RG1-991
IVIG
030219 obstetrics & reproductive medicine
In vitro fertilisation
business.industry
Low molecular weight heparin
Autoantibody
Obstetrics and Gynecology
Embryo
Embryo Transfer
030104 developmental biology
medicine.anatomical_structure
Endometrial scratching
Reproductive Medicine
Reward system
Etiology
Chronic endometritis
Female
business
Chronic Endometritis
Endometritis
Infertility
Female
Preimplantation Genetic Screening- PGS
Developmental Biology
Zdroj: Reproductive Biology and Endocrinology, Vol 16, Iss 1, Pp 1-18 (2018)
Reproductive Biology and Endocrinology : RB&E
ISSN: 1477-7827
DOI: 10.1186/s12958-018-0414-2
Popis: Recurrent implantation failure (RIF) refers to cases in which women have had three failed in vitro fertilization (IVF) attempts with good quality embryos. The definition should also take advanced maternal age and embryo stage into consideration. The failure of embryo implantation can be a consequence of uterine, male, or embryo factors, or the specific type of IVF protocol. These cases should be investigated to determine the most likely etiologies of the condition, as this is a complex problem with several variables. There are multiple risk factors for recurrent implantation failure including advanced maternal age, smoking status of both parents, elevated body mass index, and stress levels. Immunological factors such as cytokine levels and presence of specific autoantibodies should be examined, as well as any infectious organisms in the uterus leading to chronic endometritis. Uterine pathologies such as polyps and myomas as well as congenital anatomical anomalies should be ruled out. Sperm analysis, pre-implantation genetic screening and endometrial receptivity should be considered and evaluated, and IVF protocols should be tailored to specific patients or patient populations. Treatment approaches should be directed toward individual patient cases. In addition, we suggest considering a new initial step in approach to patients with RIF, individualized planned activities to activate the brain's reward system in attempt to improve immunological balance in the body.
Databáze: OpenAIRE
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