A meta-analysis of the local application of vancomycin powder to prevent surgical site infection after spinal surgeries
| Autor: | Wenfei Gu, Laiyong Tu, Shuo Shan, Jiang Zhao, Kahaer Aikenmu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Medicine (General) China medicine.drug_class Antibiotics Biochemistry antibiotics 03 medical and health sciences 0302 clinical medicine R5-920 Vancomycin medicine Humans Surgical Wound Infection Prospective Studies Retrospective Studies 030222 orthopedics business.industry Meta Analysis Biochemistry (medical) Cell Biology General Medicine surgical site infection Spinal surgery Surgery Anti-Bacterial Agents vancomycin powder clinical practice Clinical Practice meta-analysis Meta-analysis Powders business Surgical site infection 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | The Journal of International Medical Research Journal of International Medical Research, Vol 48 (2020) |
| ISSN: | 1473-2300 |
| Popis: | Objective This study aimed to systematically analyze the effectiveness and safety of the local application of vancomycin powder to prevent surgical site infection (SSI) after spinal surgeries and provide guidance for clinical practice. Methods Two researchers independently searched PubMed, Web of Science, Elsevier, and China National Knowledge Infrastructure using the MeSH terms “spinal surgery,” “vancomycin,” “local,” “topical,” “prophylactic,” “surgical site infection,” and “SSI” to identify studies published between January 2010 and January 2020 on the local application of vancomycin powder for preventing SSI after spinal surgeries. The outcome assessment indicators were analyzed using RevMan 5.3 software. Results Three randomized controlled trials, two prospective studies, and 26 retrospective studies were included in the current research. The results of the meta-analysis revealed significant differences between the vancomycin and control groups (non-vancomycin group) concerning the incidence of SSI (risk ratio = 0.39, 95% confidence interval = 0.28–0.55, Z = 5.46), indicating that local application of vancomycin powder can significantly reduce the incidence of SSI. Conclusion Local application of vancomycin powder is an effective and safe method to prevent SSI after spinal surgeries. |
| Databáze: | OpenAIRE |
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