Bones hold the key to DNA virus history and epidemiology
| Autor: | Samantha Lycett, Klaus Hedman, Mari Toppinen, Maria F. Perdomo, Antti Sajantila, Jorma Palo, Peter Simmonds, Maria Söderlund-Venermo |
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| Přispěvatelé: | Department of Virology, Medicum, Forensic Medicine, Klaus Hedman / Principal Investigator, Human Parvoviruses: Epidemiology, Molecular Biology and Clinical Impact, Virus infections and immunity, PaleOmics Laboratory |
| Rok vydání: | 2015 |
| Předmět: |
Most recent common ancestor
HUMAN PARVOVIRUS B19 Genotype World War II MARROW CELL-CULTURES Exhumation Biology Real-Time Polymerase Chain Reaction Article Bone and Bones VIRAL EVOLUTION Parvoviridae Infections EMERGENCE 03 medical and health sciences Virology INFECTION Cadaver Parvovirus B19 Human Prevalence ANCIENT DNA Humans PHYLOGENETIC ANALYSIS Phylogeny 030304 developmental biology Genetics 0303 health sciences Multidisciplinary IDENTIFICATION 030306 microbiology Viral Epidemiology Parvovirus PERSISTENCE Haplotype DNA virus History 20th Century biology.organism_classification HUMAN ERYTHROVIRUSES Europe Military Personnel Ancient DNA TISSUE Viral evolution DNA Viral REPLICATION 3111 Biomedicine USSR |
| Zdroj: | Scientific Reports Toppinen, M, Perdomo, M F, Palo, J U, Simmonds, P, Lycett, S, Soderlund-Venermo, M, Sajantila, A & Hedman, K 2015, ' Bones hold the key to DNA virus history and epidemiology ', Scientific Reports, vol. 5, 17226 . https://doi.org/10.1038/srep17226 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep17226 |
| Popis: | DNA in human skeletal remains represents an important historical source of host genomic information and potentially of infecting viruses. However, little is known about viral persistence in bone. We searched ca. 70-year-old long bones of putative Finnish casualties from World War II for parvovirus B19 (B19V) DNA and found a remarkable prevalence of 45%. The viral sequences were exclusively of genotypes 2 (n = 41), which disappeared from circulation in 1970´s, or genotype 3 (n = 2), which has never been reported in Northern Europe. Based on mitochondrial and Y-chromosome profiling, the two individuals carrying B19V genotype 3 were likely from the Soviet Red Army. The most recent common ancestor for all genotypes was estimated at early 1800s. This work demonstrates the forms of B19V that circulated in the first half of the 20th century and provides the first evidence of the suitability of bone for exploration of DNA viruses. |
| Databáze: | OpenAIRE |
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