Pregnancy associated plasma protein-A (PAPP-A) as an early marker for the diagnosis of acute coronary syndrome
| Autor: | Pradeep G Nayar, Priya Gururajan, G. Srinivasa Nageswara Rao, Prema Gurumurthy, R. Sai Babu, A. Sarasabharati, K.M. Cherian |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Acute coronary syndrome lcsh:Diseases of the circulatory (Cardiovascular) system Pregnancy-associated plasma protein A Acute coronary syndrome-Biomarker lcsh:Surgery Chest pain Gastroenterology Article Pregnancy Internal medicine Troponin I medicine Creatine Kinase MB Form Humans Pregnancy-Associated Plasma Protein-A Acute Coronary Syndrome PAPP-A-metalloproteinase Aged Receiver operating characteristic business.industry Area under the curve Emergency department lcsh:RD1-811 Middle Aged medicine.disease Atherosclerosis ROC Curve lcsh:RC666-701 Area Under Curve Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Indian Heart Journal, Vol 64, Iss 2, Pp 141-145 (2012) |
| ISSN: | 0019-4832 |
| Popis: | Aims and objectives: Pregnancy associated plasma protein-A (PAPP-A), a metalloproteinase plays a pivotal role in the pathogenesis of atherosclerosis. Recent studies have reported that elevated levels of PAPP-A, signal the onset of acute coronary syndrome (ACS). We, therefore, proposed to study the analytical competence of PAPP-A in patients admitted to the emergency department with chest pain and finally diagnosed as ACS. Methods and results: Pregnancy associated plasma protein-A was measured using enzyme-linked immunosorbent assay (ELISA) in 485 patients admitted to emergency care unit, of which 89 patients were diagnosed as Non-cardiac chest pain (NCCP). Elevated levels of PAPP-A were observed in patients diagnosed as ACS on comparison with the controls. Receiver operator characteristic (ROC) curve analysis showed PAPP-A to be a good discriminator between ischaemic and non-ischaemic patients. The area under the curve was found to be 0.904, 95% CI (0.874–0.929) with 90% sensitivity and 85% specificity (P< 0.0001). The cut-off value from the ROC curve was 0.55 μg/mL above which PAPP-A was considered to be positive. Conclusion: Pregnancy associated plasma protein-A seems to be a promising biomarker for identification and risk stratification for patients with ACS. |
| Databáze: | OpenAIRE |
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