Levels of erythromycin in tear fluid and serum in infants with conjunctivitis
| Autor: | Olof Ringertz, I. K. Sandstrom |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Staphylococcus aureus Time Factors medicine.drug_class medicine.medical_treatment Antibiotics Erythromycin Chlamydia trachomatis medicine.disease_cause Gastroenterology Minimum inhibitory concentration Conjunctivitis Bacterial Oral administration Internal medicine medicine Humans Oral erythromycin Chemotherapy General Immunology and Microbiology business.industry Erythromycin Ethylsuccinate Infant Newborn General Medicine biochemical phenomena metabolism and nutrition Conjunctivitis Inclusion Staphylococcal Infections Infectious Diseases Anesthesia Tears Purulent conjunctivitis business medicine.drug |
| Zdroj: | Scandinavian journal of infectious diseases. 20(4) |
| ISSN: | 0036-5548 |
| Popis: | 38 newborns with purulent conjunctivitis were treated with oral erythromycin ethylsuccinate 25 mg/kg every 12 h for 14 days. 3–4 days after initiation of therapy, erythromycin levels in serum and tear fluid were measured 1 and 12 h after the administration of erythromycin. The level of erythromycin in tear fluid was significantly higher than that in serum 1 and 12 h after administration of the antibiotic. On both occasions the concentrations of erythromycin in tear fluid and in serum exceeded the minimum inhibitory concentration (MIC) in vitro for Chlamydia trachomatis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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