Dual resistance to adamantanes and oseltamivir among seasonal influenza A(H1N1) viruses: 2008-2010
| Autor: | Rebecca Garten, Larisa V. Gubareva, Alexander Klimov, Yan Li, Lesley Bullion, Alicia M. Fry, Varough M. Deyde, Tiffany G. Sheu, Thein Shwe, Patrick J. Peebles |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Oseltamivir
Genotype medicine.drug_class viruses Orthomyxoviridae Mutation Missense Neuraminidase Adamantane Drug resistance Genome Viral medicine.disease_cause Antiviral Agents Virus Microbiology Viral Matrix Proteins Major Articles and Brief Reports chemistry.chemical_compound Viral Proteins Influenza A Virus H1N1 Subtype Drug Resistance Multiple Viral Influenza Human medicine Influenza A virus Immunology and Allergy Humans Clade Neuraminidase inhibitor biology virus diseases biology.organism_classification Virology respiratory tract diseases Editorial Commentary Infectious Diseases chemistry Amino Acid Substitution biology.protein RNA Viral |
| Zdroj: | The Journal of infectious diseases. 203(1) |
| ISSN: | 1537-6613 2008-2010 |
| Popis: | Two distinct genetic clades of seasonal influenza A(H1N1) viruses have cocirculated in the recent seasons: clade 2B oseltamivir-resistant and adamantane-susceptible viruses, and clade 2C viruses that are resistant to adamantanes and susceptible to oseltamivir. We tested seasonal influenza A(H1N1) viruses collected in 2008-2010 from the United States and globally for resistance to antivirals approved by the Food and Drug Administration. We report 28 viruses with both adamantane and oseltamivir (dual) resistance from 5 countries belonging to 4 distinct genotypes. Because of limited options for antiviral treatment, emergence of dual-resistant influenza viruses poses a public health concern, and their circulation needs to be closely monitored. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|