Red blood cell membrane mechanical fluctuations in non-proliferative and proliferate diabetic retinopathy
| Autor: | Galina Malkin, Shlomo Levin, Rafi Korenstein, Yair Alster, Igal Leibovitch, Anat Loewenstein, Michaella Goldstein |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Severe NPDR Angiogenesis Type 2 diabetes Cellular and Molecular Neuroscience Ophthalmology Internal medicine Erythrocyte Deformability medicine Erythrocyte deformability Humans In patient Enzyme Inhibitors Aged Adenosine Triphosphatases Aged 80 and over Glycated Hemoglobin Diabetic Retinopathy business.industry Retinal ischemia Erythrocyte Membrane Diabetic retinopathy Middle Aged medicine.disease eye diseases Sensory Systems Red blood cell Endocrinology medicine.anatomical_structure Diabetes Mellitus Type 2 Female business Fluorescein-5-isothiocyanate |
| Zdroj: | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 242(11) |
| ISSN: | 0721-832X |
| Popis: | To study whether cell membrane mechanical fluctuation (CMF) of red blood cells (RBCs) are attenuated in non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR).Point dark-field microscopy-based recordings of local membrane displacements (frequency 0.3-25 Hz) were compared between type 2 diabetes patients with mild-to-moderate and severe NPDR and type 2 diabetes patients with PDR. The matched control group, corresponding to each stage of diabetic retinopathy, was based on non-diabetic patients who were evaluated in our clinic due to cataract.The average mean values of the maximal CMF amplitude did not differ between RBCs of NPDR patients (n=20) and controls (n=20) (19.5+/-1.5% and 19.6+/-1.7%, respectively). A statistically significant decrease in CMF amplitudes was observed in patients with PDR compared with patients with a non-proliferative disease (NPDR -20%, PDR -90%).This new rheological characteristic demonstrates differences in the mechanical properties of RBCs in different stages of diabetic retinopathy. The significant reduction in CMF in patients with PDR may shed more light on the possible mechanism modulating retinal ischemia and leading to angiogenesis in these patients. Larger-scale studies are needed to evaluate these findings and the possible correlation between significantly lower CMF values and the progression of diabetic retinopathy. |
| Databáze: | OpenAIRE |
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