Gastrointestinal pathogens in anti-FH antibody positive and negative Hemolytic Uremic Syndrome
| Autor: | Shambhuprasad Kotresh Togarsimalemath, Sandrine Liguori, Aarti Gupta, Ali Si-Mohammed, Patricia Mariani-Kurkdjian, Astrid Vabret, Arvind Bagga, Marie-Agnès Dragon-Durey, Mamta Puraswani |
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| Přispěvatelé: | Complications vasculaires du diabète (CRC - Inserm U1138), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-École pratique des hautes études (EPHE)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Université Paris Descartes - Paris 5 (UPD5), École pratique des hautes études (EPHE)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Centre National de Référence des virus entériques [CHU de Dijon] (CNR virus entériques), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Department of Pediatrics, Division of Pediatric Nephrology and Genetics, All India Institute of Medical Sciences, Laboratoire de Virologie Humaine et Moleculaire, Centre National de Référence du Virus de la Rougeole et autres Paramyxoviridae respiratoires, Hôpital Universitaire Georges Clemenceau, Hôpital Robert Debré, Hôpital Européen Georges Pompidou [APHP] (HEGP), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), 'Indo-French Centre for the Promotion of Advanced Research' (IFCPAR) Grant [4703-1], École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
pneumococcal pneumonia autoantibodies 030232 urology & nephrology recipients medicine.disease_cause protein-1 03 medical and health sciences Entamoeba histolytica 0302 clinical medicine children complement factor-h Rotavirus Medicine Giardia lamblia Shigella transplant biology business.industry autoimmune form Autoantibody Clostridium difficile biology.organism_classification infection 3. Good health Complement system cfhr1/cfhr3 deficiency 030104 developmental biology Pediatrics Perinatology and Child Health Immunology [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology biology.protein Antibody business |
| Zdroj: | Pediatric Research Pediatric Research, Nature Publishing Group, 2018, 84 (1), pp.118-124. ⟨10.1038/s41390-018-0009-9⟩ |
| ISSN: | 0031-3998 1530-0447 |
| DOI: | 10.1038/s41390-018-0009-9⟩ |
| Popis: | International audience; BACKGROUND: Prodromal symptoms are frequently reported in the atypical form of Hemolytic uremic syndrome (aHUS) suggesting implication of infectious triggers. Some pathogens may also play a role in the mechanisms of production of autoantibody directed against Factor H (FH), a complement regulator, leading to aHUS.METHODS: The presence of 15 gastrointestinal (GI) pathogens was investigated by using xTAG-based multiplex PCR techniques on stools collected at the acute phase in a cohort of Indian HUS children classified according to the presence or absence of anti-FH autoantibodies.RESULTS: Prevalence of pathogens in patients with anti-FH antibody (62.5%) was twice that in those without (31.5%). Different pathogens were detected, the most frequent being Clostridium difficile, Giardia intestinalis, Salmonella, Shigella, Rotavirus, Norovirus and Entamoeba histolytica. No stool was positive for Shigatoxin.CONCLUSION: This study reveals a higher prevalence of GI pathogens in anti-FH positive than in negative patients. No single pathogen was implicated exclusively in one form of HUS. These pathogens may play a role in the disease initiation by inducing complement activation or an autoimmune response. |
| Databáze: | OpenAIRE |
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