Enhancement of Dose Response and Nuclear Magnetic Resonance Image of PAGAT Polymer Gel Dosimeter by Adding Silver Nanoparticles
| Autor: | Arman Sedghi, Najmeh Deyhimihaghighi, Rahim Sabbaghizadeh, Roslinda Shamsudin |
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| Rok vydání: | 2017 |
| Předmět: |
Polymers
Acrylic Resins Cancer Treatment Metal Nanoparticles lcsh:Medicine Nanoparticle 02 engineering and technology Gelatin Silver nanoparticle Diagnostic Radiology Polymerization 030218 nuclear medicine & medical imaging chemistry.chemical_compound 0302 clinical medicine Medicine and Health Sciences Nanotechnology lcsh:Science Multidisciplinary Radiology and Imaging Chemical Reactions Gamma ray 021001 nanoscience & nanotechnology Magnetic Resonance Imaging Chemistry Oncology Macromolecules Optical Equipment Absorbed dose Physical Sciences Engineering and Technology 0210 nano-technology Research Article Chemical Elements Clinical Oncology Silver food.ingredient Materials science Imaging Techniques Materials by Structure Materials Science Polyacrylamide Radiation Therapy Equipment Research and Analysis Methods 03 medical and health sciences Organophosphorus Compounds food Diagnostic Medicine Humans Dosimeter business.industry Radiotherapy Planning Computer-Assisted Lasers lcsh:R Dose-Response Relationship Radiation Polymer Chemistry chemistry Nanoparticles lcsh:Q Clinical Medicine Nuclear medicine business Nuclear chemistry |
| Zdroj: | PLoS ONE, Vol 12, Iss 1, p e0168737 (2017) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | In the present study, the normoxic polyacrylamide gelatin and tetrakis hydroxy methyl phosphoniun chloride (PAGAT) polymer gel dosimeters were synthesized with and without the presence of silver (Ag) nanoparticles. The amount of Ag nanoparticles varied from 1 to 3 ml with concentration 3.14 g/l, thus forming two types of PAGAT polymer gel dosimeters before irradiating them with 6 to 25 Gy produced by 1.25-MeV 60Co gamma rays. In this range, the predominant gamma ray interaction with matter is by Compton scattering effect, as the photoelectric absorption effect diminishes. MRI was employed when evaluating the polymerization of the dosimeters and the gray scale of the MRI film was determined via an optical densitometer. Subsequent analyses of optical densities revealed that the extent of polymerization increased with the increase in the absorbed dose, while the increase of penetration depth within the dosimeters has a reverse effect. Moreover, a significant increase in the optical density-dose response (11.82%) was noted for dosimeters containing 2 ml Ag nanoparticles. |
| Databáze: | OpenAIRE |
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