Estimating the value of novel interventions for Parkinson's disease: An early decision-making model with application to dopamine cell replacement
| Autor: | Ola Ghatnekar, Ulf Persson, Olle Lindvall, Peter Hagell, Jan Reimer, Martin Grabowski, Jonas Hjelmgren |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
medicine.medical_specialty Neurology Parkinson's disease Cost effectiveness Cost-Benefit Analysis Dopamine Decision Making Psychological intervention Disease outcomes Sensitivity and Specificity Indirect costs Physical medicine and rehabilitation Humans Medicine cost-effectiveness health care economics and organizations Aged Aged 80 and over Neurons therapy Cost–benefit analysis business.industry modeling Parkinson Disease Genetic Therapy cell Middle Aged medicine.disease Disease Progression Quality of Life Physical therapy Economic model Neurology (clinical) Geriatrics and Gerontology business Models Econometric Stem Cell Transplantation |
| Zdroj: | Parkinsonism & Related Disorders; 12(7), pp 443-452 (2006) |
| ISSN: | 1353-8020 1873-5126 |
| DOI: | 10.1016/j.parkreldis.2006.04.006 |
| Popis: | A long-term cost-effectiveness model for early decision-making and estimation of outcomes of novel therapeutic procedures for Parkinson's disease (PD) was developed based on the Hoehn and Yahr (HY) stages of PD. Results provided support for model validity. Model application to a future dopamine cell replacement therapy indicated long-term cost offsets and gains in quality-adjusted life years (QALYs) in early onset PD (HY III-IV), as compared to standard drug therapy. The maximum price premium (i.e., profit or compensation for developmental costs) for the intervention to remain cost-effective was estimated to EURO12000-64000 according to cost-per-QALY thresholds of EURO38000-70000 and depending on whether all or only medical direct costs are considered. The study illustrates the value of early health economic modeling and the described model shows promise as a means to estimate outcomes and aid decision-making regarding novel interventions for PD. (c) 2006 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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