Isozymes of P5C reductase (PYCR) in human diseases: focus on cancer
| Autor: | Chien-An Andy Hu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
biology
Organic Chemistry Clinical Biochemistry Cell Mitochondrion Reductase NAD Proteomics Biochemistry Isozyme Cofactor Mitochondria Isoenzymes medicine.anatomical_structure Neoplasms biology.protein medicine Animals Humans Pyrroline Carboxylate Reductases Amino Acid Sequence NAD+ kinase Gene NADP |
| Zdroj: | Amino Acids. 53:1835-1840 |
| ISSN: | 1438-2199 0939-4451 |
| DOI: | 10.1007/s00726-021-03048-x |
| Popis: | Δ1-Pyrroline-5-carboxylate (P5C) reductase (PYCR or P5CR) catalyzes the conversion of P5C to L-proline (Pro) with concomitant oxidation of a cofactor, NADPH or NADH. Mammalian PYCR have been studied since 1950' and currently three isozymes of human PYCR, 1, 2, and L, have been identified and characterized and their roles in genetic diseases and cancer biology have been keenly investigated. These three isozymes are encoded by three different genes localized at three different chromosomes, and catalyze NAD(P)H-dependent reduction of P5C to Pro important for the transfer of oxidizing potential across the mitochondrion and cell. The review summarizes the current understanding of these three human PYCR isozymes and their roles in diseases with a focus on cancer. |
| Databáze: | OpenAIRE |
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