Coronary Artery Flow Velocity Is Related To Lumen Area and Regional Left Ventricular Mass
| Autor: | Yvonne Stuart, Michael Stokes, H V Anderson, Subhi A. Abu-Halawa, Miltiadis N Leon, Richard L. Kirkeeide |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Blood Pressure Coronary Artery Disease Coronary Angiography symbols.namesake Coronary circulation Heart Rate Coronary Circulation Physiology (medical) Internal medicine Heart rate medicine Humans Aged medicine.diagnostic_test business.industry Coronary flow reserve Middle Aged Echocardiography Doppler Blood pressure medicine.anatomical_structure Flow velocity Angiography Cardiology symbols Female Hypertrophy Left Ventricular Cardiology and Cardiovascular Medicine business Doppler effect Blood Flow Velocity Artery |
| Zdroj: | Circulation. 102:48-54 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.102.1.48 |
| Popis: | Background —Coronary flow velocity varies widely between individuals, even at rest. Because of this variation, indices with less apparent deviation, such as the ratio of hyperemic to resting velocity (coronary flow reserve), have been more commonly studied. We tested the hypothesis that the flow continuity principle could be used to model resting coronary flow, and we examined the resulting velocity relationship. Methods and Results —We studied coronary velocity in 59 patients using a Doppler wire to measure resting and hyperemic average peak velocities in the left anterior descending artery. Quantitative techniques were used to calculate lumen cross-sectional area and the lengths of all distal coronary branches. Branch lengths were used to estimate regional left ventricular mass. We then calculated the ratio of lumen area to regional mass (A/m). Regional perfusion was estimated from the double product of heart rate and systolic blood pressure. Resting velocity (V) varied inversely with A/m ratio [V=46.5/(A/m); r =0.68, P 2 /100 g, respectively; P P =0.06). Conclusions —Resting coronary artery flow velocity is inversely related to the ratio of lumen area to regional left ventricular mass. Higher resting velocities are found when insufficient lumen size exists for the distal myocardial bed, as occurs with diffuse mild or moderate coronary atherosclerosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|