Human antibody responses to the Anopheles salivary gSG6-P1 peptide : a novel tool for evaluating the efficacy of ITNs in malaria vector control
| Autor: | Franck Remoue, Patrick Besnard, Filomeno Fortes, Mbacké Sembène, Anne Poinsignon, Maria Adelaide Dos-Santos, François Simondon, Jacques Le Mire, Vincent Foumane, Sylvie Cornelie, Papa M. Drame, J.C. Toto, Pierre Carnevale |
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| Přispěvatelé: | Institut de Recherche pour le Développement (IRD), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Saliva
Epidemiology Anopheles gambiae [SDV]Life Sciences [q-bio] lcsh:Medicine Mosquitoes Immunoglobulin G 0302 clinical medicine MESH: Animals lcsh:Science Immune Response MESH: Immunoglobulin G 0303 health sciences Multidisciplinary biology MESH: Peptides Anopheles MESH: Salivary Proteins and Peptides MESH: Enzyme-Linked Immunosorbent Assay MESH: Antibody Formation 3. Good health MESH: Angola Infectious Diseases Biomarker (medicine) Medicine Antibody Research Article Infectious Disease Control 030231 tropical medicine Immunology MESH: Malaria Malaria vector control Enzyme-Linked Immunosorbent Assay Infectious Disease Epidemiology MESH: Anopheles 03 medical and health sciences parasitic diseases medicine Parasitic Diseases Animals Humans MESH: Saliva Salivary Proteins and Peptides Biology 030304 developmental biology MESH: Humans lcsh:R Tropical Diseases (Non-Neglected) Vectors and Hosts biology.organism_classification medicine.disease Malaria Biomarker Epidemiology Angola Antibody Formation biology.protein MESH: Biomarkers lcsh:Q [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Peptides Biomarkers |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2010, 5 (12), pp.e15596. ⟨10.1371/journal.pone.0015596⟩ PLoS ONE, 2010, 5 (12), pp.e15596. ⟨10.1371/journal.pone.0015596⟩ PLoS ONE, Vol 5, Iss 12, p e15596 (2010) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0015596⟩ |
| Popis: | International audience; To optimize malaria control, WHO has prioritised the need for new indicators to evaluate the efficacy of malaria vector control strategies. The gSG6-P1 peptide from gSG6 protein of Anopheles gambiae salivary glands was previously designed as a specific salivary sequence of malaria vector species. It was shown that the quantification of human antibody (Ab) responses to Anopheles salivary proteins in general and especially to the gSG6-P1 peptide was a pertinent biomarker of human exposure to Anopheles. The present objective was to validate this indicator in the evaluation of the efficacy of Insecticide Treated Nets (ITNs). A longitudinal evaluation, including parasitological, entomological and immunological assessments, was conducted on children and adults from a malaria-endemic area before and after the introduction of ITNs. Significant decrease of anti-gSG6-P1 IgG response was observed just after the efficient ITNs use. Interestingly, specific IgG Ab level was especially pertinent to evaluate a short-time period of ITNs efficacy and at individual level. However, specific IgG rose back up within four months as correct ITN use waned. IgG responses to one salivary peptide could constitute a reliable biomarker for the evaluation of ITN efficacy, at short- and long-term use, and provide a valuable tool in malaria vector control based on a real measurement of human-vector contact. |
| Databáze: | OpenAIRE |
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