A New 2,3-Dimethyl Butenolide from the Brittle Star Ophiomastix mixta
| Autor: | Kwang Sik Im, Jongki Hong, Jee H. Jung, Sook Shin, Jin Soo Lee, Chong-Ok Lee, Weihong Wang |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Molecular Structure
Ophiomastix biology Stereochemistry Chemistry Monoterpene Antineoplastic Agents General Chemistry General Medicine biology.organism_classification 4-Butyrolactone Brittle star Cell Line Tumor Drug Discovery Animals Humans Organic chemistry Spectral data Cytotoxicity Solid tumor Echinodermata Butenolide |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 55:459-461 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | A new butenolide (1) was isolated, along with a known acyclic polyhalogenated monoterpene (2), from the brittle star Ophiomastix mixta. The structures were defined by analysis and comparision of the spectral data with those in the literature. The 2,3-dimethyl butenolide (1) is uncommon and first encountered in a marine organism. The compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines and displayed mild to significant activity. |
| Databáze: | OpenAIRE |
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