Further observations on the role of the MHC genes and certain hearing disorders
| Autor: | Joel M. Bernstein, Frederick M. Schaffer, Thomas C. Shanahan |
|---|---|
| Přispěvatelé: | University of Groningen |
| Rok vydání: | 1996 |
| Předmět: |
EXPRESSION
Pathology medicine.medical_specialty Hearing loss Hearing Loss Sensorineural Population Genes MHC Class II Presbycusis Genes MHC Class I COMMON VARIABLE IMMUNODEFICIENCY SUSCEPTIBILITY Major histocompatibility complex major histocompatibility complex genes strial presbycusis MHC class I otorhinolaryngologic diseases medicine Humans education Meniere Disease FRAGMENT education.field_of_study biology business.industry Histocompatibility Testing Haplotype Meniere's disease STEROID 21-HYDROXYLASE General Medicine CLASS-III GENES medicine.disease COMPONENT POLYMORPHISM MAJOR HISTOCOMPATIBILITY COMPLEX DEFICIENCY Blotting Southern Otosclerosis sensorineural hearing disorders Otorhinolaryngology Haplotypes Case-Control Studies Immunology biology.protein medicine.symptom business |
| Zdroj: | Acta oto-Laryngologica, 116(5), 666-671 |
| ISSN: | 0001-6489 |
| Popis: | The pathogenetic mechanism of many hearing disorders have not been fully defined. Studies of certain hearing disorders in man have suggested a role for the major histocompatibility complex (MHC)-encoded genes in disease pathogenesis. In a cohort of unrelated patients with Meniere's Disease, otosclerosis and strial presbycusis as well as other types of sensorineural hearing losses, we have identified an extended MHC haplotype common to the majority of these patients, supporting a hypothesis that a gene(s) within the MHC domain may confer susceptibility to these hearing ailments. In addition, a preliminary study of 27 individuals with various hearing maladies, a striking finding is that 44% of the patients express the following extended MHC haplotype in contrast to only 7% of the general population: DQw2-DR3-C4BSf-C4A0-G11:15-Bf:0.4-C2a-HSP70:7.5-TNF a5-B8-Cw7-A1. The expression of this haplotype by subsets of patients with hearing loss is significant in comparison to regional and international controls. |
| Databáze: | OpenAIRE |
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