Two distinct cellular proteins interact with the EIa-responsive element of an adenovirus early promoter
| Autor: | B Reimund, M. Wintzerith, C Kedinger, P. Jansen-Durr, C. Hauss |
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| Rok vydání: | 1990 |
| Předmět: |
Transcriptional Activation
Molecular Sequence Data Immunology Alpha (ethology) medicine.disease_cause Binding Competitive Microbiology Adenoviridae Transactivation Virology medicine Humans Binding site Promoter Regions Genetic E2F Transcription factor Base Sequence biology Hybridization probe Adenovirus Early Proteins Oncogene Proteins Viral biology.organism_classification Molecular biology Mastadenovirus Insect Science biological phenomena cell phenomena and immunity DNA Probes HeLa Cells Transcription Factors Research Article |
| Zdroj: | Journal of Virology. 64:2384-2387 |
| ISSN: | 1098-5514 0022-538X |
| Popis: | EIa-dependent transactivation of the adenovirus EIIa early (EIIaE) promoter is correlated with the activation of the cellular transcription factor E2F. In this study we identified a cellular protein, C alpha, that is distinct from E2F and that binds two sites in the EIIaE promoter, one of which overlaps with the proximal E2F binding site of the EIIaE promoter. The possible involvement of C alpha in the EIa responsiveness of this promoter is discussed. |
| Databáze: | OpenAIRE |
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