Controllability affects endocrine response of adolescent male rats to stress as well as impulsivity and behavioral flexibility during adulthood
Autor: | Antonio Armario, Arnau Ramos-Prats, Jaume F. Lalanza, Roser Nadal, Jesús Úbeda-Contreras, Maria Sanchís-Ollé, Silvia Fuentes |
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Rok vydání: | 2019 |
Předmět: |
Male
0301 basic medicine Serial reaction time medicine.medical_specialty lcsh:Medicine Endocrine System Audiology Impulsivity Choice Behavior Article 03 medical and health sciences Cognition 0302 clinical medicine Stress (linguistics) Reaction Time medicine Animals Humans Endocrine system Risk factor lcsh:Science Estrès en els adolescents Multidisciplinary Behavior Animal Receptors Dopamine D2 business.industry lcsh:R Age Factors Cognitive flexibility Models animals Flexibility (personality) Corpus Striatum Rats 030104 developmental biology Delay Discounting Impulsive Behavior lcsh:Q medicine.symptom business Stress Psychological 030217 neurology & neurosurgery |
Zdroj: | Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | Altres ajuts: ESF/PEJ-2014-A-51463 Altres ajuts: ESF/FEDER7S-20IU16-0019 Altres ajuts: ESF/BES-2015-071464 Exposure to stress during adolescence exerts a long-term impact on behavior and might contribute to the development of several neuropsychiatric disorders. In adults, control over stress has been found to protect from the negative consequences of stress, but the influence of controllability at early ages has not been extensively studied. Here, we evaluated in a rodent model the effects of repeated exposure in adolescent male rats to controllable versus uncontrollable foot-shock stress (CST or UST, respectively). Rats were assigned to three groups: non-stress (stress-naïve), CST (exposed to 8 sessions of a two-way shuttle active avoidance task over a period of 22 days) and UST (receiving the same amount of shocks as CST, regardless of their actual behavior). During adulthood, different cohorts were tested in several tasks evaluating inhibitory control and cognitive flexibility: 5-choice serial reaction time, delay-discounting, gambling test and probabilistic reversal learning. Results showed that the hypothalamic-pituitary-adrenal response to the first shock session was similar in CST and UST animals, but the response to the 8 session was lower in CST animals. In adulthood, the UST animals presented impaired motor (but not cognitive) impulsivity and more perseverative behavior. The behavioral effects of UST were associated with increased number of D2 dopamine receptors in dorsomedial striatum, but not in other striatal regions. In summary, UST exposure during adolescence induced long-term impairments in impulsivity and compulsivity, whereas CST had only minor effects. These data support a critical role of stress uncontrollability on the long-lasting consequences of stress, as a risk factor for mental illnesses. |
Databáze: | OpenAIRE |
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