Treatment of Mycobacterium avium-intracellulare Complex Infection in Beige Mice with Free and Liposome-Encapsulated Streptomycin: Role of Liposome Type and Duration of Treatment
| Autor: | Pattisapu R. J. Gangadharam, Daniel S. Friend, Diana L. Flasher, Naheed Ghori, Dilip R. Ashtekar, Nejat Düzgüneş, Robert J. Debs |
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| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.drug_class medicine.medical_treatment Mycobacterium avium-intracellulare infection Antibiotics Spleen Biology Injections Intramuscular Microbiology Mice medicine Animals Freeze Fracturing Immunology and Allergy Tissue Distribution Lung Mycobacterium avium-intracellulare Infection Drug Carriers Chemotherapy Liposome Aminoglycoside Mycobacterium avium Complex medicine.disease Mice Inbred C57BL Microscopy Electron Infectious Diseases medicine.anatomical_structure Liver Streptomycin Injections Intravenous Liposomes Microscopy Electron Scanning Drug carrier medicine.drug |
| Zdroj: | Journal of Infectious Diseases. 164:143-151 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Current treatments for Mycobacterium avium-intracellulare complex (MAC) infections are generally ineffective. Thus, the potential of free or liposome-encapsulated streptomycin to treat acute MAC infection was investigated in beige mice. Free streptomycin administered intramuscularly 5 days a week (150 mg/kg) was effective in the liver, spleen, and lungs. At 4 weeks, liposome-encapsulated streptomycin, administered intravenously in weekly doses (15 mg/kg), reduced the colony-forming units in the liver and spleen by about the same extent as a 50- to 100-fold higher dose of free drug. With 4 weekly injections of liposomes, the colony-forming units in the liver and spleen were lower by 2.4 and 2.9 log units, respectively, compared to untreated controls, even by the end of 12 weeks. The effects of unilamellar and multilamellar liposomes were similar. These observations suggest that liposome encapsulation not only targets streptomycin to infected cells but also increases the residual activity of the drug. |
| Databáze: | OpenAIRE |
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