Decoupling of the amygdala to other salience network regions in adolescent-onset recurrent major depressive disorder
| Autor: | Scott A. Langenecker, Olusola Ajilore, David T. Hsu, Marta Peciña, K. L. Phan, Jon Kar Zubieta, Alyssa Barba, Lisanne M. Jenkins, Kelly A. Ryan, Jennifer R. Gowins, Heide Klumpp, Rachel H. Jacobs, Brian J. Mickey, Robert C. Welsh, Magdalena Sikora |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Ventromedial prefrontal cortex Gyrus Cinguli Brain mapping Article Executive Function Young Adult 03 medical and health sciences 0302 clinical medicine Recurrence Neural Pathways medicine Humans Psychiatry Applied Psychology Default mode network Anterior cingulate cortex Brain Mapping Depressive Disorder Major medicine.diagnostic_test business.industry Amygdala medicine.disease Magnetic Resonance Imaging Frontal Lobe 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Frontal lobe Case-Control Studies Posterior cingulate Major depressive disorder Female Functional magnetic resonance imaging business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Psychological Medicine. 46:1055-1067 |
| ISSN: | 1469-8978 0033-2917 |
| Popis: | BackgroundRecent meta-analyses of resting-state networks in major depressive disorder (MDD) implicate network disruptions underlying cognitive and affective features of illness. Heterogeneity of findings to date may stem from the relative lack of data parsing clinical features of MDD such as phase of illness and the burden of multiple episodes.MethodResting-state functional magnetic resonance imaging data were collected from 17 active MDD and 34 remitted MDD patients, and 26 healthy controls (HCs) across two sites. Participants were medication-free and further subdivided into those with single v. multiple episodes to examine disease burden. Seed-based connectivity using the posterior cingulate cortex (PCC) seed to probe the default mode network as well as the amygdala and subgenual anterior cingulate cortex (sgACC) seeds to probe the salience network (SN) were conducted.ResultsYoung adults with remitted MDD demonstrated hyperconnectivity of the left PCC to the left inferior frontal gyrus and of the left sgACC to the right ventromedial prefrontal cortex (PFC) and left hippocampus compared with HCs. Episode-independent effects were observed between the left PCC and the right dorsolateral PFC, as well as between the left amygdala and right insula and caudate, whereas the burden of multiple episodes was associated with hypoconnectivity of the left PCC to multiple cognitive control regions as well as hypoconnectivity of the amygdala to large portions of the SN.ConclusionsThis is the first study of a homogeneous sample of unmedicated young adults with a history of adolescent-onset MDD illustrating brain-based episodic features of illness. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|