Development and Optimization of Self-emulsifying Drug Delivery Systems (SEDDS) for Enhanced Dissolution and Permeability of Rosuvastatin
| Autor: | H. Y. Karasulu, Ercument Karasulu, Uğur Önsel Türk, Sebnem Apaydin, Candeger Yilmaz, Evren Gundogdu, Tugce Turgay, I. Yildırım Şimşir |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Statin
Cell Survival medicine.drug_class Biological Availability Pharmaceutical Science 02 engineering and technology Pharmacology 030226 pharmacology & pharmacy Permeability Glycerides Polyethylene Glycols 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine medicine Humans Rosuvastatin Rosuvastatin Calcium Solubility Chemistry nutritional and metabolic diseases 021001 nanoscience & nanotechnology Bioavailability Drug Liberation Permeability (electromagnetism) Drug delivery Emulsions Ethylene Glycols Caco-2 Cells Hydroxymethylglutaryl-CoA Reductase Inhibitors 0210 nano-technology Drug carrier Oleic Acid Tablets medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1567-2018 |
| DOI: | 10.2174/156720181303160520211640 |
| Popis: | Rosuvastatin calcium is commonly used statin for treatment of dyslipidemia. It has low bioavailability. The aim of this study was to develop new rosuvastatin calcium self-emulsifying drug delivery systems (SEDDS) as an alternative formulation and to evaluate the permeability of rosuvastatin calcium SEDDS by using Caco-2 cells. Rosuvastatin calcium SEDDSs were developed by using pseudo ternary phase diagram and characterized by using heating cooling cycle, robustness to dilution, stability and in vitro drug release and permeability. The permeability studies of rosuvastatin calcium SEDDS (Papp (A→B) for F1-RS=1.492×10-5±0.413×10-5 and Papp (A→B) for F2-RS=1.254×10-5±0.19×10-5) across Caco-2 cells showed that permeability value from apical to basolateral was higher than permeability value of commercial formulation (Papp (A→B) =7.13×10-5±0.668×10-5). In conclusion, SEDDS as a drug carrier may be used as an effective and alternative hyperlipidemia therapy for oral delivery of rosuvastatin calcium. |
| Databáze: | OpenAIRE |
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